Analysis of physiological regulation of tRNA from the view of its intracellular dynamics.

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Recently, many researchers are interested in various regulations of tRNA function in the cytoplasm and in tRNA fragments as signaling molecules. In this project, I performed molecular genetical analyses with budding yeast as a model organism to understand relation between tRNA fragmentation in the cytoplasm and the yeast splicing system, difference in stability between mature tRNAs and introns produced by cytoplasmic splicing, and mechanism of nuclear import and export of tRNAs, which determines nuclear-cytoplasmic balance of tRNAs.