Studies on the epigenetic regulation of meiosis/sporulation in the budding yeast Saccharomyces serevisiae

我们探索了Rpd3/HDAC在出芽酵母酿酒酵母减数分裂/孢子形成的发生和进展中的作用，发现如下：1) Rpd3的HDAC活性在诱导早期减数分裂基因IME2时受到至少包括Hac1和Set3在内的多个因子的协同抑制。2) Rpd3/HDAC通过促进Sum1/Hst1转录抑制因子的释放，正调控NDT80的表达，NDT80编码减数分裂中后期/裂解基因的关键调控因子。

We explored the function of Rpd3/HDAC on the initiation and progression of meiosis/sporulation inthe budding yeast Saccharomyces cerevisiae, and found the followings. 1) HDAC activity of Rpd3 is repressed by the cooperation of multiple factors including at least Hac1 and Set3 upon induction of early-meiotic gene IME2. 2) Rpd3/HDAC positively regulates the expression of NDT80, encoding a key regulator of mid- and late-meiotic/spoluration genes, through facilitating the release of Sum1/Hst1 transcriptional repressor.