Evaluation of the biomarker of the prognosis in dogs with thoracolumbar intervertebral disc disease

犬胸腰椎间盘疾病预后生物标志物的评价

• 批准号: 22580367
• 负责人: UENO Hiroshi
• 金额: $ 2.33万
• 依托单位: Rakuno Gakuen University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22580367/
• 关键词: 犬; 椎間板疾患; 予後判定因子; マトリックスメタロプロテイナーゼ; 軟骨異栄養犬種; 血清; ゼラチンザイモグラフィー; マトリクスメタロプロテイナーゼ; MMP活性値; 歯周病; 歯肉; 軟骨異栄養種犬; 予後因子; 椎間板髄核

Canine progressive myelomalacia (PM) is a death-dealing disease which happen in succession to acute thoracolumbar intervertebral disc hernia (IVDH). Therefore, in order to determine a treatment policy, it is important to evaluate a possibility that in early stages of IVDH comes worse at PM. However, the sure factor for evaluating the possibility of PM generating does not exist. In this study, the matrix metalloproteinase (MMP) activity in serum of acute thoracolumbar IVDH dogs was evaluated. As a result, the serum MMP activity of PM case was increased than that of the healthy dog significantly. The MMP activity in serum of PM case was also increased than that of IVDH cases without deep pain (Grade V; GV) significantly. From these results, a possibility that the MMP activity value in serum would be applicable as an evaluation factor of PM generating was suggested.

犬进行性骨髓瘤软化症（PM）是继急性胸腰椎椎间盘突出症（IVDH）之后发生的一种致命疾病。因此，为了确定治疗策略，重要的是评估早期IVDH在PM时恶化的可能性。然而，评价PM产生可能性的确定因子并不存在。本研究对急性胸腰椎IVDH犬血清基质金属蛋白酶（MMP）活性进行了测定。结果表明，PM病例血清MMP活性明显高于正常犬。PM患者血清MMP活性也明显高于无深度疼痛（V级；GV）的IVDH患者。由此可见，血清中MMP活性值可作为PM生成的评价因子。

项目成果

Evaluation of matrix metalloproteinase (MMP)-9 as a biomarker of the prognosis in dogs with thoracolumbar intervertebral disc hernia (IVDH)

基质金属蛋白酶（MMP）-9作为胸腰椎间盘突出症（IVDH）犬预后生物标志物的评估

• 发表时间: 2013
• 作者: H. Ueno;Y. Fujisaki;T. Matsunagi;S. Isoda;H. Soma;K. Fujita
• 通讯作者: K. Fujita

健常犬における血清中マトリックスメタロプロテイナーゼ-9活性の評価

健康犬血清基质金属蛋白酶9活性评价

• 发表时间: 2013
• 作者: 磯田成志;藤崎雄介;馬緤智之;相馬浩晶;藤田和繁;上野博史
• 通讯作者: 上野博史

犬の胸腰部椎間板ヘルニアの予後判定因子としての血清中Matrix Metalloproteinase-9 (MMP- 9)の有用性

血清基质金属蛋白酶-9 (MMP-9) 作为犬胸腰椎间盘突出症预后因素的有用性

• 发表时间: 2013
• 作者: 上野博史;藤崎雄介;馬緤智之;磯田成志;相馬浩晶;藤田和繁
• 通讯作者: 藤田和繁