Effect of one-lung ventilation on acute lung injury

单肺通气对急性肺损伤的影响

• 批准号: 21791465
• 负责人: UENO Hiroshi
• 金额: $ 2.5万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791465/
• 关键词: 一側肺換気; 急性肺損傷; ARDS; 虚脱肺; 炎症性メディエータ; 人工呼吸関連肺損傷; 炎症性メディエーター; 低酸素性肺血管収縮

The aim of this study was to investigate the effect of one-lung ventilation(OLV) on acute lung injury(ALI), especially in relation to re-inflated after deflated lung. This experiment involved general anesthetized rats. OLV was performed for 60min, and then double-lung ventilation(DLV) was performed 60min(OLV group). Only DLV was performed for 120min(control group). No destructive change was observed in the control group. On the contrary, destruction of pulmonary cell walls, migration of inflammatory cells, and pulmonary hemorrhages were present in OLV group. In OLV group, such damaged change in deflated lung was more remarkable than in ventilated lung. Inflammatory cytokine(TNF-α、IL-1β、IL-6、IL-8), HMGB1 concentrations in both plasma and bronchoalveolar lavage fluid(BALF) in OLV group tended to be higher than in control group. Particularly in OLV group, HMGB1 concentration in BALF in deflated lung was higher than in ventilated lung. In conclusion, ALI following the OLV had possibility to caused by effect of deflated lung as well as injury of ventilated lung.

本研究的目的是探讨单肺通气（OLV）对急性肺损伤（ALI）的影响，特别是与肺瘪气后重新充气的影响。该实验涉及全身麻醉的老鼠。进行OLV 60 min，然后进行双肺通气（DLV）60 min（OLV 组）。仅进行DLV 120min（对照组）。对照组没有观察到破坏性变化。相反，OLV组则出现肺细胞壁破坏、炎症细胞迁移、肺出血等现象。在OLV组中，瘪肺的这种损伤变化比通气肺更显着。 OLV组血浆和支气管肺泡灌洗液(BALF)中炎性细胞因子(TNF-α、IL-1β、IL-6、IL-8)、HMGB1浓度均高于对照组。特别是在OLV组中，瘪肺中BALF中HMGB1浓度高于通气肺中。综上所述，OLV后的ALI很可能是由肺收缩和通气损伤引起的。

项目成果

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