Study of HMGB protein : development of therapy and therapeutic drugs for ALI/ARDS
Study of HMGB protein : development of therapy and therapeutic drugs for ALI/ARDS
批准号:
18791095
负责人:
UENO Hiroshi
金额:
$1.9万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2006
资助国家:
日本
项目状态:
已结题
起止时间:
2006 至 2008
中文摘要
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英文摘要
HMGBI、HMGB2の様々なエピトープを認識するモノクローナル抗体を急性肺傷害モデルマウスに気管内投与すると、HMGB1とHMGB2の相同性が最も低い部位をエピトープとする抗体が肺傷害軽減に最も効果的であり、HMGB2に特異性が高い抗体ほど肺傷害軽減効果は低い。また、健常マウスにHMGB抗体を投与すると、ほとんどのマウスが死亡することより、HMGB蛋白は生理的に重要な役割をしていると推察されたが、その役割までは解明できなかった。
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
人工換気による肺損傷発生における細胞外ATPの関与
细胞外 ATP 参与人工通气引起的肺损伤的发生
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[松山広樹, 天谷文昌, 橋本壮志, 上野博司, 橋本悟]
通讯作者:
橋本悟
DOI:
10.1152/ajplung.90250.2008
发表时间:
2008-10-01
期刊:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
影响因子:
4.9
作者:
[Hashimoto, Soshi, Amaya, Fumimasa, Hashimoto, Satoru]
通讯作者:
Hashimoto, Satoru
DOI:
10.1186/1465-9921-9-79
发表时间:
2008-12-13
期刊:
RESPIRATORY RESEARCH
影响因子:
5.8
作者:
[Matsuyama, Hiroki, Amaya, Fumimasa, Hashimoto, Satoru]
通讯作者:
Hashimoto, Satoru
Elucidation of operation mechanism of rotary molecular motors by comparison with the mechanisms of F1 and V1-ATPases.
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批准号:25840053
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.66万
-
财政年份:2013
-
负责人:UENO Hiroshi
-
依托单位:
Development of the isolation method for repellent compounds that appeal to the instinct as to think of the natural enemy of deerand/or wild boar
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批准号:23658274
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.58万
-
财政年份:2011
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负责人:UENO Hiroshi
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依托单位:
Development of the quantitative evaluation method of a salty enhancing effect
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批准号:22300258
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$13.06万
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财政年份:2010
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负责人:UENO Hiroshi
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依托单位:
Evaluation of the biomarker of the prognosis in dogs with thoracolumbar intervertebral disc disease
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批准号:22580367
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.33万
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财政年份:2010
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负责人:UENO Hiroshi
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依托单位:
Effect of one-lung ventilation on acute lung injury
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批准号:21791465
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.5万
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财政年份:2009
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负责人:UENO Hiroshi
-
依托单位:
Evaluation of Mongolian Public Financial System and Policy Using PEFA-PMF and CPIA on Fiscal Policy
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批准号:19530256
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2007
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负责人:UENO Hiroshi
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依托单位:
Evaluation of Economic Transition Policies and International Assistance for Cental Asian Transition Countries : the Case of Mongolia
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批准号:15530187
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
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财政年份:2003
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负责人:UENO Hiroshi
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依托单位:
Large production and purification of glutamate decarboxylase and application for diagnosing diabetes mellitus
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批准号:10556018
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.31万
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财政年份:1998
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负责人:UENO Hiroshi
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依托单位:
Structural studies on the chemically and genetically engineered protein with high pressure as a denaturant
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批准号:08680652
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.6万
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财政年份:1996
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负责人:UENO Hiroshi
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依托单位:
Studies of substrate recognition mechanism on brain glutamate decarboxylase
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批准号:06670155
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1994
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负责人:UENO Hiroshi
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依托单位:
Studies on gossypol, a spermatocidal, anti-viral and anti-parasitic agent
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批准号:04670153
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1992
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负责人:UENO Hiroshi
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依托单位:
海外基金