How does a telogen-elevated growth factor regulate hair growth?

休止期升高的生长因子如何调节头发生长？

• 批准号: 22590078
• 负责人: IMAMURA Toru
• 金额: $ 2.83万
• 依托单位: National Institute of Advanced Industrial Science and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590078/
• 关键词: 細胞生物学; 細胞増殖因子; 毛成長; 毛成長周期; 休止期; FGF; シグナル; 受容体; 毛包; コンディショナルノックアウト; 発生・分化; 繊維芽細胞増殖因子; FGF18; 脱毛症; 形態形成; 毛包幹細胞

Hair follicles repeatedly cycle through growth (anagen), regression (catagen), and resting (telogen) phases. Although the signaling molecules involved in the anagen and anagen–catagen transition have been studied extensively, the signaling that controls telogen is only partly understood. Here we show that fibroblast growth factor (Fgf)18 is expressed in a hair stem cell niche throughout telogen, and that it regulates the hair cycle through the non-growth phases. When the Fgf18 gene is conditionally knocked out in keratin 5-positive epithelial cells in mice, telogen becomes very short, giving rise to a strikingly rapid succession of hair cycles. In wild-type mice, hair follicle growth during anagen is strongly suppressed by local delivery of FGF18 protein. Our results demonstrate that epithelial FGF18 signaling and its reduction in the milieu of hair stem cells are crucial for the maintenance of resting and growth phase, respectively.

毛囊在生长期(生长期)、退化期(退化期)和静止期(休止期)反复循环。虽然参与生长期和生长期-退化期转变的信号分子已经被广泛研究，但对控制端原的信号还只有部分了解。在这里，我们显示成纤维细胞生长因子(成纤维细胞生长因子)18在整个端粒期的毛发干细胞中表达，并通过非生长阶段调节毛发周期。当Fgf18基因在小鼠角蛋白5阳性的上皮细胞中有条件地被敲除时，端原变得非常短，导致毛发周期惊人地快速接连。在野生型小鼠中，毛囊在生长期的生长受到局部FGF18蛋白的强烈抑制。我们的结果表明，上皮性FGF18信号及其在毛发干细胞环境中的减少分别对维持静止期和生长期至关重要。

项目成果

産総研:発毛サイクルの「休止期」を維持 する因子を発見

AIST：发现维持毛发生长周期静止期的因子

Cyclic Epithelial FGF18 Signaling Regulates Hair Cycle Resting Phase

环状上皮 FGF18 信号传导调节毛发周期静止期

• 发表时间: 2014
• 作者: 工藤冴;丸山康介;高木美奈子; 町田拓自;飯塚健治;平藤雅彦;今村 亨
• 通讯作者: 今村 亨

FGF18 signaling in regressing and resting phases of hair growth cycle in mice

FGF18 信号在小鼠毛发生长周期的退行期和休止期中的作用

• 发表时间: 2011
• 作者: 植木美穂;織田裕子;倉持明子;浅田眞弘;鈴木理;今村亨
• 通讯作者: 今村亨

Morphogenesis of proto hair follicles in vitro and effects of growth factor signaling

体外原毛囊的形态发生和生长因子信号传导的影响

• 发表时间: 2010
• 作者: 植木美穂;織田裕子;本田絵美;今村亨
• 通讯作者: 今村亨

発毛サイクルの「休止期」を維持する因子を発見

发现维持毛发生长周期“休止期”的因子