Roles of intracellular signaling through lysophospholipid receptors in synovial cells in rheumatoid arthritis pathogenesis.

在类风湿关节炎（RA）中，炎性细胞浸润到滑膜组织并释放炎性介质，导致滑膜炎和关节结构的破坏。在这些炎症介质中，溶血磷脂酸（LPA）在RA滑膜细胞中的作用机制尚不清楚。此外，RA滑液的酸化也有报道，提示滑膜细胞周围的酸性环境在RA发病机制中的重要性。在这项研究中，我们分析了RA滑膜细胞的细胞反应。结果提示，除炎性细胞因子外，关节液中LPA和关节液酸化可能是RA发病的重要因素。

In rheumatoid arthritis (RA), inflammatory cells infiltrate into thesynovial tissues and release inflammatory mediators which result in synovitis anddestruction of articular structure. Of these inflammatory mediators, the action mechanismof lysophosphatidic acid (LPA) in RA synoviocytes is still unclear. Furthermore, theacidification of RA synovial fluid has been reported, suggesting the importance of acidiccondition surrounding synovial cells in RA pathogenesis. In this study, we analysedcellular responses in RA synovial cells. Our results suggested that, in addition toinflammatory cytokines, LPA in synovial fluid and acidification of synovial fluid may becritical components in RA pathogenesis.