Effect of nano-sized zinc oxide and titanium oxide on autoimmune diseases and its mechanisms
Effect of nano-sized zinc oxide and titanium oxide on autoimmune diseases and its mechanisms
批准号:
22590125
负责人:
YOSHINO Shin
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
研究了纳米氧化锌和氧化钛对自身免疫性疾病的影响。胶原诱导的小鼠关节炎(CIA)被用作自身免疫性疾病的模型,并给予不同剂量的这些纳米材料。结果,两种纳米材料都未能影响CIA。然而,这些材料似乎增加了Th2细胞因子的产生,这表明它们可能影响Th2依赖性过敏性疾病。
英文摘要
The effect of nano-sized zinc oxide and titanium oxide on autoimmune diseases was investigated. Collagen-induced arthritis (CIA) in mice was used as a model of autoimmune diseases and various doses of these nanomaterials were administered. As a result, both nano-sized materials failed to influence CIA. However, the materials appeared to increase the production of Th2 cytokines, suggesting that they might affect Th2-dependent allergic diseases.
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DOI:
10.1111/all.12000
发表时间:
2012-10
期刊:
Allergy
影响因子:
12.4
作者:
[Kouya Yamaki;Shin Yoshino]
通讯作者:
Kouya Yamaki;Shin Yoshino
抗原特異的IgEモノクローナル抗体により産生増強されたIgG1の喘息症状に及ぼす影響
抗原特异性 IgE 单克隆抗体增强 IgG1 产生对哮喘症状的影响
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[伊藤裕子, 後藤智美, 渡邉美奈恵, 棚橋高志, 猪飼誉友, 大島晴美, 三上栄一, 水谷暢明]
通讯作者:
水谷暢明
DOI:
10.1016/j.ejphar.2011.12.020
发表时间:
2012-02-29
期刊:
EUROPEAN JOURNAL OF PHARMACOLOGY
影响因子:
5
作者:
[Nabe, Takeshi, Ikedo, Ayumu, Chaplin, David D.]
通讯作者:
Chaplin, David D.
DOI:
10.1186/1476-9255-8-31
发表时间:
2011-11-04
期刊:
Journal of inflammation (London, England)
影响因子:
--
作者:
[Koobkokkruad T, Kadotani T, Hutamekalin P, Mizutani N, Yoshino S]
通讯作者:
Yoshino S
Complement C3a-induced IL-17 plays a critical role in an IgE-mediated late-phase asthmatic responses
补体 C3a 诱导的 IL-17 在 IgE 介导的晚期哮喘反应中发挥关键作用
DOI:
--
发表时间:
2012
期刊:
Journal of Immunology
影响因子:
4.4
作者:
[Tsuchiya H, Matsunaga T, Aikawa K, Kamada N, Nakamura K, Ichikawa H, Sasaki K, Ohmori S., Nobuaki Mizutani]
通讯作者:
Nobuaki Mizutani
共 16 条
Studies on the effect of nanoparticles on oral tolerance
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批准号:19590129
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2007
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负责人:YOSHINO Shin
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依托单位:
Effect of Kosa on Th1 and Th2 immune responses and on oral tolerance
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批准号:16590099
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2004
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负责人:YOSHINO Shin
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依托单位:
Studies on the effect of genetically modified foods on oral tolerance
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批准号:14572117
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:2002
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负责人:YOSHINO Shin
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依托单位:
Studies on the effect of endocrine disrupters on autoimmune disease and its mechanisms
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批准号:11839018
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:1999
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负责人:YOSHINO Shin
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依托单位:
Studies on the effect of diesel exhaust particles on autoimmune disease and its mechanisms
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批准号:09672237
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.86万
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财政年份:1997
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负责人:YOSHINO Shin
-
依托单位:
海外基金