Development of pioneering therapy for early atherosclerosis using novel S1P donor
Development of pioneering therapy for early atherosclerosis using novel S1P donor
批准号:
22590139
负责人:
FUJII Satoshi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
A novel strategy for conquering atherosclerosis is desirable. Athero-protective HDL is rich in bioactive lipid, sphingosine-1-phosphate (S1P). The effect of S1P on vascular endothelial cells was clarified. The relationship between plasma S1P and vascular endothelial function was evaluated. A newly synthesized biomimetic HDL nanoparticle rich in both S1P and apoA1 exhibited promising anti-inflammatory effects on endothelial cells in culture and on mice challenged with LPS.
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S1Pが血液線溶系に与える影響の解明
阐明S1P对血液纤溶系统的影响
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[真川明将, 岩城壮一郎, 浅井萌子, 榊原大輔, 山村周平, 藤井聡]
通讯作者:
藤井聡
金ナノ粒子を核とした人工 HDL ナノ粒子の調製と物性評価
以金纳米粒子为核心的人工HDL纳米粒子的制备及物性评价
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[高橋 朋弘, 田上 辰秋, 岩城 壮一郎, 藤井 聡, 尾関 哲也]
通讯作者:
尾関 哲也
Posttranscriptional regulation of expression of plasminogen activator inhibitor type-1 by sphingosine 1-phosphate in HepG2 liver cells. Biochimica et Biophysica Acta
HepG2 肝细胞中 1-磷酸鞘氨醇对 1 型纤溶酶原激活剂抑制剂表达的转录后调节。
DOI:
--
发表时间:
2012
期刊:
Biochimica et Biophysica Acta
影响因子:
--
作者:
[Sun X, Zhang M, Sanagawa A, Mori C, Ito S, Iwaki S, Satoh H, Fujii S., Sugiura T, Tanaka K, Iwaki S]
通讯作者:
Iwaki S
Physicochemical properties of macrogol ointment and emulsion ointment blend developed for regulation of water absorption
为调节吸水率而开发的聚乙二醇软膏和乳液软膏混合物的理化性质
DOI:
10.1016/j.ijpharm.2011.07.034
发表时间:
2011
期刊:
Int J Pharmaceut
影响因子:
5.8
作者:
[Noda Y, Watanabe K, Sanagawa A, Sobajima Y, Fujii S.]
通讯作者:
Fujii S.
Critical role of water diffusion into matrix in external use iodine preparations.
水扩散到外用碘制剂基质中的关键作用。
DOI:
10.1016/j.ijpharm.2010.05.009
发表时间:
2010
期刊:
International Journal of Pharmaceutics
影响因子:
5.8
作者:
[Noda Y, Fujii S.]
通讯作者:
Fujii S.
共 34 条
Elucidation of metabolic mechanisms focusing on genomic abnormalities and epigenomic changes related to tumor-bearing state and drug resistance
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批准号:19K07769
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
-
财政年份:2019
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负责人:FUJII Satoshi
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依托单位:
Research on technological development of narrative communication in public and its applicability
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批准号:15K14047
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
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财政年份:2015
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负责人:FUJII Satoshi
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依托单位:
Development of Early Diagnosis System for Alzheimer's Disease by Electrochemical Detection of Amyloid beta peptide
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批准号:26350552
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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财政年份:2014
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负责人:FUJII Satoshi
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依托单位:
The effects of endogenous adenosine on hippocampal synaptic plasticity induced by low-frequency stimulayion
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批准号:24500434
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2012
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负责人:FUJII Satoshi
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依托单位:
Basic research for development of novel switch part on conformation and delivery of nucleic acid
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批准号:22590039
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2010
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负责人:FUJII Satoshi
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依托单位:
Study of Mobility Management for the introduction of sharing system of personal vehicles
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批准号:22360206
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.65万
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财政年份:2010
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负责人:FUJII Satoshi
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依托单位:
Investigation of chromatin remodeling by histone modifier protein in carcinogenesis and progression.
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批准号:21590453
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2009
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负责人:FUJII Satoshi
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依托单位:
Development of Nitric Oxide Responsible Peptide-Metal Complex Conjugate and Its Application
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批准号:19550170
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2007
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负责人:FUJII Satoshi
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依托单位:
Investigation of role of histone modifier protein in carcinogenesis and carcinoma cell progression
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批准号:19590417
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
-
财政年份:2007
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负责人:FUJII Satoshi
-
依托单位:
LTP suppression induced by preconditioning inputs to hippocampal CA3 synapses
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批准号:19500317
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.41万
-
财政年份:2007
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负责人:FUJII Satoshi
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依托单位:
Study on management measures to change attitude and behavior in transportation planning.
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批准号:17360244
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.63万
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财政年份:2005
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负责人:FUJII Satoshi
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依托单位:
A study on prescriptions for social consensus building in society where there are diverse values
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批准号:14208041
-
项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$23.21万
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财政年份:2002
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负责人:FUJII Satoshi
-
依托单位:
DEVELOPMENT OF NEW THERAPY FOR ATHEROSCLEROSIS TARGETING NATURAL KILLER T (NKT) CELLS
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批准号:14370215
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.9万
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财政年份:2002
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负责人:FUJII Satoshi
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依托单位:
Dynamic structure of biological related molecules : X-ray determination and Molecular dynamic simulation
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批准号:14572035
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.43万
-
财政年份:2002
-
负责人:FUJII Satoshi
-
依托单位:
Elucidation of the determinants of atherosclerosis progression in transplanted hearts using bone marrow transplantation
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批准号:12670641
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.56万
-
财政年份:2000
-
负责人:FUJII Satoshi
-
依托单位:
Oxygen semi-permeation and electrical conducting behavior of electronic and oxide ionic conducting ceramics
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批准号:11650699
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.54万
-
财政年份:1999
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负责人:FUJII Satoshi
-
依托单位:
Structural bases of the functional nucleic acids as the therapeutic target
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批准号:10470476
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$6.53万
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财政年份:1998
-
负责人:FUJII Satoshi
-
依托单位:
Elucidation of accelerated atherosclerosis in cardiac transplantation
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批准号:10670621
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
-
财政年份:1998
-
负责人:FUJII Satoshi
-
依托单位:
The Molecular Recognition Mechanism of Nucleic Acid Structure by Beta-Turn Motif of Protein
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批准号:01571177
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.22万
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财政年份:1989
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负责人:FUJII Satoshi
-
依托单位:
海外基金