Intercellular electrical connections by changes in the membrane potential of intracellular calcium stores

通过细胞内钙库膜电位的变化实现细胞间电连接

• 批准号: 22590211
• 负责人: YAMASHITA Masayuki
• 金额: $ 2.91万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590211/
• 关键词: 生体膜; チャネル; トランスポーター; 能動輸送; オルガネラ; 発生; 再生生理学; 細胞内カルシウムストア; カルシウム放出; 膜電位変動; 電位感受性蛍光色素; 核膜; ゆらぎ; 同期; 網膜

Intracellular calcium stores are formed from the endoplasmic reticulum and the nuclear envelope. In the present study, it was revealed in retinal neuroepithelial cells that the membrane potential of the nuclear envelope is altered by the release of calcium from intracellular calcium stores and that synchronous spike discharges are caused by capacitative currents associated with the voltage changes of the nuclear envelope. Moreover, it was found that an extracellular voltage gradient exists in the retinal neuroepithelium. The presence of an endogenous electrical potential gradient was necessary for the correct guidance of retinal ganglion cell axons.

细胞内的钙储存由内质网和核膜形成。在本研究中，它揭示了在视网膜神经上皮细胞的核膜的膜电位被改变从细胞内钙库的钙的释放和同步尖峰放电所引起的电容电流与电压变化的核膜。此外，发现视网膜神经上皮细胞中存在细胞外电压梯度。内源性电位梯度的存在对于视网膜神经节细胞轴突的正确引导是必要的。

项目成果

Neuroepithelium potential: Electric axon guidance by extracellular voltage gradient

神经上皮电位：细胞外电压梯度引导电轴突

• 发表时间: 2012
• 作者: Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;山下勝幸;山下勝幸;M.Yamashita;山下勝幸;Masayuki Yamashita
• 通讯作者: Masayuki Yamashita

Electric axon guidance in embryonic retina: Galvanotropism revisited

• DOI: 10.1016/j.bbrc.2012.12.115
• 发表时间: 2013-02-08
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Yamashita, Masayuki

Nuclear envelope potential : An origin of the first correlated neural activity

核膜电位：第一个相关神经活动的起源

• DOI: 10.1016/j.neures.2011.07.1366
• 发表时间: 2011
• 期刊: Neuroscience Research
• 影响因子: 2.9
• 作者: Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita
• 通讯作者: Masayuki Yamashita

細胞外電位勾配による網膜神経節細胞の軸索誘導

细胞外电位梯度对视网膜神经节细胞的轴突引导

• 发表时间: 2012
• 作者: Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;山下勝幸;山下勝幸;M.Yamashita;山下勝幸;Masayuki Yamashita;山下勝幸;Masayuki Yamashita;Masayuki Yamashita;山下勝幸
• 通讯作者: 山下勝幸

細胞外電位勾配による軸索ガイダンス

通过细胞外电位梯度引导轴突

• 发表时间: 2012
• 作者: Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;Masayuki Yamashita;山下勝幸;山下勝幸;M.Yamashita;山下勝幸
• 通讯作者: 山下勝幸