Investigation of the role of ABCF2, a regulator of cell volume, in induction of apoptosis.

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I found that the COOH-terminal region (amino acid 591- 616) of ABCF2 is necessary for its accumulation in the 100,000×g pellet after hypotonic stimulation.On the other hand, I found that the content of ACTN4 accumulated in the 100,000× g pellet significantly increased, while the content of ABCF2 did not change, after the application of H_2O_2 or staurosporine. My results showed that this region was not necessary to regulate the behavior of ABCF2 after the application of H_2O_2 or staurosporine. The single-cell size measurements also revealed that AVD was not seenin cells expressing ABCF2 deletion mutant lacking this region.