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Advanced investigation of molecular regulation of lipid metabolism by the transcription factor Nrf1

Advanced investigation of molecular regulation of lipid metabolism by the transcription factor Nrf1
转录因子Nrf1对脂质代谢分子调控的深入研究
批准号:
22590277
负责人:
KOBAYASHI Akira
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
The experimental purpose of this project is to investigate regulatory mechanisms of the transcription factor Nrf1(NF-E2-related factor 1) for lipid metabolism. First, we found that the turnover of Nrf1 is regulated by the ubiquitin ligase Hrd1 and β-TrCP in the cytoplasm and nucleus, respectively. Second, we identified that proteasome subunit genes psmc4 and psmb6 were direct Nrf1 target genes.
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会议论文
リン酸化による転写因子Nrf1の機能制御機構の解析
转录因子Nrf1磷酸化功能调控机制分析
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [伊藤義起, 他]
通讯作者:
DOI: 10.1161/circresaha.109.211417
发表时间: 2010-03-19
期刊: CIRCULATION RESEARCH
影响因子: 20.1
作者: [Pepe, Anna Elena, Xiao, Qingzhong, Xu, Qingbo]
通讯作者: Xu, Qingbo
DOI: 10.1128/mcb.05663-11
发表时间: 2011-11-01
期刊: MOLECULAR AND CELLULAR BIOLOGY
影响因子: 5.3
作者: [Tsuchiya, Yoshiki, Morita, Tomoko, Kobayashi, Akira]
通讯作者: Kobayashi, Akira
DOI: 10.1111/j.1365-2443.2011.01522.x
发表时间: 2011-06-01
期刊: GENES TO CELLS
影响因子: 2.1
作者: [Kobayashi, Akira, Tsukide, Takako, Yamamoto, Masayuki]
通讯作者: Yamamoto, Masayuki
7
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