Brain regions that are involved in psychogenic fever

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We investigated if stress-induced hyperthermia (SIH) is nlediated by the activation of the vesicular glutamate transporter 3 (VGLUT3)-positive sympathetic premotor neurons in the rostral medullary raphe region in a similar manner as infection/inflammation-induced fever. Rats exposed to social defeated stress exhibited a rapid increase in abdominal temperature and induced Fos, a marker of neuronal activation, in the VGLUT3-expressing neurons in the rostral medullary raphe region. Pretreatment with diazepam attenuated both SIH and Fos expression in these regions. These findings suggest that SIH is mediated by the VGLUT3-positive sympathetic premotor neurons in the rostral medullary raphe region.