The role of microtubules structure in hepatitis C virus replicationand the possibility of its target molecule for anti-HCV agent

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We previously found that the antifungal agent, Griseofulvin, hasa suppressive effect on HCV replication. On the basis of this result, we optimized thestructure of Griseofulvin for searching a new candidate compound of an anti-HCV agentamong Griseofulvin analogues, and analyzed molecular mode of action of Griseofulvinagainst HCV replication. Consequently, we found two Griseofulvin analogues were moreeffective in suppressing HCV replication than Griseofulvin. However, we were unable toclarify molecular mode of action of Griseofulvin against HCV replication.