Phenotypic analyses for differentiationof human iPS cells into cardiomyocytes

人 iPS 细胞分化为心肌细胞的表型分析

• 批准号: 22590813
• 负责人: MURATA Mitsushige
• 金额: $ 3.08万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590813/
• 关键词: iPS 細胞; 心筋細胞; イオンチャネル; 心筋再生; iPS細胞

Human iPS-derived cardiomyocytes showed the nodal phenotypic features in molecular biological and electrophysiological analyses at the early period of differentiation, whereas they showed ventricular and atrial phenotypes at the late period. These results

在分子生物学和电生理学分析中，人iPS衍生的心肌细胞在分化早期表现出结节表型特征，而在分化晚期表现出心室和心房表型。这些结果

项目成果

Frequent long-distance flyer's undersirable mileage : an organized giant thrombus stuck in PFO

经常长途飞行的不理想里程：PFO 内有组织的巨大血栓

• 发表时间: 2012
• 期刊: J Thromb Thrombolysis
• 作者: Katsumata Y;et al
• 通讯作者: et al

A novel in vivoDrosophia RNAi screen identifies NOT3 as a conserved regulator of heart function.

一种新颖的体内果蝇 RNAi 筛选将 NOT3 鉴定为心脏功能的保守调节因子。

• 发表时间: 2010
• 期刊: Cell
• 影响因子: 64.5
• 作者: Neely GG;Kuba K,Cammarato A;Isobe K;Amann S;Zhang L;Murata M;Elmen L;Gupta V;Arora S;Sarangi R;Dan D;Fujisawa S;Usami T;Xia CP;Keene AC;Alayari KN;Yamakawa H;Elling U;Berger C;Novatchkova M;Koglgruber R;Fukuda K;Nishina H;Isobe M;P
• 通讯作者: P

Frequent long-distance flyer's undersirable mileage: an organized giant thrombus stuck in PFO.

经常长途飞行的人的不良里程：有组织的巨大血栓卡在 PFO 中。

• 发表时间: 2012
• 期刊: J Thromb Thrombolysis.
• 作者: Katsumata Y;Kimura K;Sano M;Kudo M;Arai T;Ohno Y;Tamura Y;Tsuruta H;Murata M;Yozu R;Fukuda K.
• 通讯作者: Fukuda K.

Significance of electrocardiographic right ventricular hypertrophy in patients with pulmonary hypertension or without right ventricular systolic dysfunction

肺动脉高压或无右心室收缩功能障碍患者心电图右心室肥厚的意义

• 发表时间: 2012
• 期刊: Intern Med
• 作者: Satoshi Okumura S;Wenqian Cai;Meihua Jin;Yunzhe Bai;Takashi Tsunematsu;Yuko Hidaka;Reiko Kurotani;Yoshihiro Ishikawa;赤阪隆史;Nagai T
• 通讯作者: Nagai T

A non-genetic method for purifying stem cell-derived cardiomyocytes.

一种纯化干细胞来源的心肌细胞的非遗传方法。

• 发表时间: 2010
• 期刊: Nature Methods
• 影响因子: 48
• 作者: Hattori F;Chen H;Yamashita H;Tohyama S;Satoh Y;Yuasa S;Li W;Yamakawa H;Tanaka T;Onitsuka T;Shimoji K;Ohno Y;Egashira T;Kaneda R;Murata M;Hidaka K;Morisaki T;Sasaki E;Suzuki T;Sano M;Makino S;Oikawa S;Fukuda K.
• 通讯作者: Fukuda K.