Analysis of adult T-cell leukemia cells using multi-color flow cytometry can detect high risk asymptomatic HTLV-1 carriers to progress into adult T-cell leukemia.

使用多色流式细胞术对成人 T 细胞白血病细胞进行分析，可以检测出进展为成人 T 细胞白血病的高风险无症状 HTLV-1 携带者。

• 批准号: 22591028
• 负责人: UCHIMARU Kaoru
• 金额: $ 2.33万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591028/
• 关键词: HTLV-1; ATL; FACS; TSLC1; CADM1; CD7; ＨＴＬＶ－１; ＡＴＬ; ＦＡＣＳ; ＴＳＬＣ１; ＣＡＤＭ１; ＣＤ７; ＣＣＲ４; TSLC-1; HTLV-1キャリア; リスクファター

ATL cells can be detected as CADM1+/CD7- cells using multi-color fllow cytometry and this analysis is helpful for monitoring therapeutic effect for ATL. This technique can purify the cells in intermediate state of oncogensis of HTLV-1 infected cells to ATL as CADM1+/CD7dim cells. These CADM1+/CD7dim cells is detected in the peripheral blood of a part of asymptomatic carriers at high risk to develop ATL.

采用多色流式细胞术可检测到ATL细胞为CADM 1 +/CD 7-细胞，该分析有助于ATL治疗效果的监测。该技术可将处于HTLV-1感染细胞致瘤中间状态的细胞纯化为ATL作为CADM 1 +/CD 7 dim细胞。这些CADM 1 +/CD 7 dim细胞在一部分无症状携带者的外周血中检测到，这些携带者具有发展ATL的高风险。

项目成果

The CD3 versus CD7 plot in multicolor flow cytometry reflects progression of disease stage in patients infected with HTLV-I.

• DOI: 10.1371/journal.pone.0053728
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Kobayashi S;Tian Y;Ohno N;Yuji K;Ishigaki T;Isobe M;Tsuda M;Oyaizu N;Watanabe E;Watanabe N;Tani K;Tojo A;Uchimaru K
• 通讯作者: Uchimaru K

Arinobu Tojo and Kaoru Uchimaru Leukemic T cells are specifically enriched in aunique CD3dimCD7low subpopulation of CD4+ T cells in acute-type adult T-cell leukemia.

Arinobu Tojo 和 Kaoru Uchimaru 白血病 T 细胞在急性型成人 T 细胞白血病中特有的 CD3dimCD7low CD4 T 细胞亚群中富集。

• 发表时间: 2011
• 期刊: Cancer Sci.
• 作者: Yamin Tian;Seiichro Kobayashi;Nobuhiro Ohno;Masamichi Isobe;Mayuko Tsuda;Yuji Zaike;Nobukazu Watanabe;Kenzaburo Tani
• 通讯作者: Kenzaburo Tani

Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan

无症状 HTLV-1 携带者的人类 T 细胞白血病病毒 I 型（HTLV-1）前病毒载量和疾病进展：日本的一项全国性前瞻性研究

• DOI: 10.1182/blood-2009-12-257410
• 发表时间: 2010-08-26
• 期刊: BLOOD
• 影响因子: 20.3
• 作者: Iwanaga, Masako;Watanabe, Toshiki;Yamaguchi, Kazunari
• 通讯作者: Yamaguchi, Kazunari

Nation-wide survey of the management of adult T-cell leukemia and HTLV-1 carrier

全国成人 T 细胞白血病和 HTLV-1 携带者管理调查

• 发表时间: 2011
• 作者: Uchimaru K;et al.
• 通讯作者: et al.

Leukemic T cells are specifically enriched in a unique CD3dimCD7low subpopulation of CD4+ T cells in acute-type adult T-cell leukemia

• DOI: 10.1111/j.1349-7006.2010.01833.x
• 发表时间: 2011-03-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Tian, Yamin;Kobayashi, Seiichro;Uchimaru, Kaoru
• 通讯作者: Uchimaru, Kaoru