Carcinogenesis of human neuroblastoma from human neural stem cell

我们已经从人iPS细胞中获得了人神经干细胞，并研究了外源癌基因N-myc的诱导能否转化该细胞。我们会在发育的不同阶段准备人类或小鼠的神经干细胞。N-myc基因在细胞内被诱导。观察其对细胞增殖的影响。这些研究可能反映正常细胞向癌细胞的转化，以阐明其致癌机制。

We have made human neural stem cell from human iPS cell and investigated whether the induction of exogenous oncogene N-myc could transform the cell or not. We would prepare human or mouse neural stem cells at various step of the development. And N-myc genes were induced in the cells. The effect on cell proliferation was observed. These studies may reflect the cellular transformation from the normal cells to the cancer cells to clarify the mechanism of the carcinogenesis.