Research of revolutionary kidney regeneration for hereditary nephritis using a mouse model

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Recent observations have revealed that the activation of nuclear factor κB (NF-κB) plays an important role in minimal- change nephrotic syndrome (MCNS), and there is a theory that therapeutic efficacy of steroids in MCNS is associated with the inhibition of NF-κB activity. Dehydroxy-methyl-epoxyquinomicin (DHMEQ) is a newly developed inhibitor of NF-κB that directly binds specifically to NF-κB components to inhibit DNA binding. Therefore, it is thought to be more specific than most other NF-κB inhibitors.We conducted this study to determine whether DHMEQ may ameliorate puromycin aminonucleoside (PAN)-induced nephrosis in a murine model for MCNS. As a result, DHMEQ could reduce the albuminuria and ameliorate the hypercholesterolemia and hypoalbuminemia in comparison with PAN injection without DHMEQ in the mice. DHMEQ also inhibited PAN-induced NF-κB translocation from the cytoplasm to the nucleus. In conclusion, NF-κB plays an important role in the pathogenesis of MCNS, and these results suggest that DHMEQ is a candidate therapeutic agent for MCNS.