Optimization of local cerebral cortical thickness measurement and comparison of cortical thickness and cortical volume data

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In this study, we extracted the regional cerebral cortical structural information from 3 dimensional T1-weighted magnetic resonance images using several segmentation algorithms. We compared cortical thickness data with cortical volumes and volumetric loss of brain tissue among the same subject groups in a voxel-wise manner. Although we observed significant regional structural changes in all the methods, spatial distribution with significant changes were different among algorithms, which suggested these methods have different types of information regarding brain structures.