Voxel-based analysis of the diffusion tensor in psychiatric diseases

基于体素的精神疾病扩散张量分析

• 批准号: 15591259
• 负责人: ABE Osamu
• 金额: $ 2.18万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591259/
• 关键词: magnetic resonance imaging; diffusion tensor; amyotrophic lateral sclerosis; normal agin; posttraumatic stress disorder; statistical parametric mapping; diffusion tensor tractography; magnetic resonance imaging; diffusion tensor; amyotrophic late

Recent functional neuroimaging work has suggested that interregional functional connectivity between the anterior cingulate cortex (ACC), other limbic, and prefrontal regions may be involved in the pathophysiology of posttraumatic stress disorder (PTSD). However, less attention has been paid to the white matter network. Voxel-based analysis enables an exploration of morphological or functional changes throughout the entire brain. Here we undertook the first application of this technology to diffusion tensor data in patients with PTSD. Participants were 9 victims of the Tokyo subway sarin attack with PTSD and 16 matched victims of the same traumatic event without PTSD. The voxel-based analysis showed a significant fractional anisotropy increase in the left anterior cingulum, subjacent to the left ACC gray matter where we previously found volume decrement, in PTSD subjects. Moreover, the severity was positively, but not significantly associated with the fractional anisotropy of the left anterior cingulum in the victims with PTSD, using the region of interest defined in the native space with the inverse normalization technique. The present study demonstrated further evidence of abnormalities of both the ACC, a structure which is pivotally involved in attention, emotional regulation, and fear conditioning, and of subjacent white matter in the pathology of PTSD.

最近的功能神经影像学工作表明，前扣带皮层（ACC）、其他边缘和前额叶区域之间的区域间功能连接可能与创伤后应激障碍（PTSD）的病理生理学有关。然而，对白质网络的关注较少。基于体素的分析可以探索整个大脑的形态或功能变化。在这里，我们首次将该技术应用于 PTSD 患者的弥散张量数据。参与者包括 9 名患有 PTSD 的东京地铁沙林毒气袭击受害者和 16 名没有 PTSD 的同一创伤事件的匹配受害者。基于体素的分析显示，在 PTSD 受试者中，左前扣带区（位于左 ACC 灰质下方）的各向异性分数显着增加，我们之前发现该处的体积减少。此外，使用逆归一化技术在本地空间中定义的感兴趣区域，严重程度与 PTSD 受害者左前扣带回各向异性分数呈正相关，但不显着相关。本研究进一步证明了 ACC（一种在注意力、情绪调节和恐惧调节中起关键作用的结构）和 PTSD 病理学中的下白质异常的证据。

项目成果

Neuroanatomy in monozygotic twins with Asperger disorder discordant for comorbid depression.

患有阿斯伯格症的同卵双胞胎的神经解剖学与共病抑郁症不一致。

• 发表时间: 2005
• 期刊: Neurology 65(3)
• 作者: Yamasue H;Ishijima M;Abe O;Sasaki T;Yamada H;Suga M;Rogers M;Minowa I;Someya R;Kurita H;Aoki S;Kato N;Kasai K.
• 通讯作者: Kasai K.

ALS早期診断のための新しい展開-拡散テンソルMRIによる検討

ALS早期诊断新进展——弥散张量MRI研究

• 发表时间: 2004
• 期刊: 神経内科 60(3)
• 作者: 阿部 修;青木茂樹;増谷佳孝他
• 通讯作者: 増谷佳孝他

阿部 修, 青木茂樹, 増谷佳孝他: "筋萎縮性側索硬化症における早期診断-拡散テンソルMRIによる検討"神経内科. (発売予定). (2004)

Osamu Abe、Shigeki Aoki、Yoshitaka Masutani 等人：“肌萎缩侧索硬化症的早期诊断 - 使用扩散张量 MRI 的研究”《神经病学》（计划发布）。

Neuroanatomy in monozygotic twins with Asperger disorder discordant for comorbid depression

患有阿斯伯格症的同卵双胞胎的神经解剖学与共病抑郁症不一致

• 发表时间: 2005
• 期刊: Neurology 65(3)
• 作者: Yamasue H;Ishijima;M;Abe O;et al.
• 通讯作者: et al.

Voxel-based diffusion tensor analysis reveals aberrant anterior cingulum integrity in posttraumatic stress disorder due to terrorism

• DOI: 10.1016/j.pscychresns.2006.01.004
• 发表时间: 2006-04-30
• 期刊: PSYCHIATRY RESEARCH-NEUROIMAGING
• 影响因子: 2.3
• 作者: Abe, Osamu;Yamasue, Hidenori;Ohtomo, Kuni
• 通讯作者: Ohtomo, Kuni