Analysis of tumor hypoxia in lung cancer using real time mass spectrometry

在肺腺癌中，SUVmax、HIF1α和GLUT1的表达与多种与恶性和无病生存相关的临床病理因素相关。我们得出结论，在肺腺癌（而非鳞状细胞癌）中，hif1 α-诱导的GLUT1表达在病理上表明肿瘤具有侵袭性，这可能解释了PET对FDG的高摄取并与不良预后相关。我们还发现脯氨酸和谷氨酸代谢可能在5-FU诱导的细胞死亡中发挥作用。

In lung adenocarcinoma, the SUVmax and the expression of HIF1α and GLUT1 correlated with various clinicopathological factors relating to malignancy and disease free survival. We conclude that in lung adenocarcinoma, but not squamous cell carcinoma, HIF1α-induced GLUT1 expression indicates tumor aggressiveness pathologically, and might explain high FDG uptake on PET and correlate with poor prognosis. We also show that proline and glutamate metabolism may play a role in 5-FU induced cell death using real time mass spectrometry.