Analysis of tumor hypoxia in lung cancer using real time mass spectrometry

实时质谱分析肺癌肿瘤缺氧

• 批准号: 22591567
• 负责人: MIYATA Yoshihiro
• 金额: $ 2.75万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591567/
• 关键词: 呼吸器外科学; FDG-PET; 肺癌; メタボローム; 肺がん; 質量分析

In lung adenocarcinoma, the SUVmax and the expression of HIF1α and GLUT1 correlated with various clinicopathological factors relating to malignancy and disease free survival. We conclude that in lung adenocarcinoma, but not squamous cell carcinoma, HIF1α-induced GLUT1 expression indicates tumor aggressiveness pathologically, and might explain high FDG uptake on PET and correlate with poor prognosis. We also show that proline and glutamate metabolism may play a role in 5-FU induced cell death using real time mass spectrometry.

在肺腺癌中，SUVmax 以及 HIF1α 和 GLUT1 的表达与恶性肿瘤和无病生存相关的各种临床病理因素相关。我们的结论是，在肺腺癌（而非鳞状细胞癌）中，HIF1α 诱导的 GLUT1 表达在病理上表明肿瘤的侵袭性，并且可能解释 PET 上的高 FDG 摄取并与不良预后相关。我们还使用实时质谱法表明脯氨酸和谷氨酸代谢可能在 5-FU 诱导的细胞死亡中发挥作用。

项目成果

Use of high-resolution computed tomography and positron emission tomography/computed tomography in the management of stage IA adenocarcinoma.

高分辨率计算机断层扫描和正电子发射断层扫描/计算机断层扫描在 IA 期腺癌治疗中的应用。

• DOI: 10.1053/j.semtcvs.2012.10.006
• 发表时间: 2012
• 期刊: Seminars in thoracic and cardiovascular surgery
• 影响因子: 2.5
• 作者: Y. Miyata;Y. Tsutani;M. Okada
• 通讯作者: M. Okada

Prognostic significance of metabolic response by positron emission tomography after neoadjuvant chemotherapy for resectable malignant pleural mesothelioma

• DOI: 10.1093/annonc/mds537
• 发表时间: 2013-04-01
• 期刊: ANNALS OF ONCOLOGY
• 影响因子: 50.5
• 作者: Tsutani, Y.;Takuwa, T.;Okada, M.
• 通讯作者: Okada, M.

Metabolomic analysis of dynamic response and drug resistance of gastric cancer cells to 5-fluorouracil.

• DOI: 10.3892/or.2012.2182
• 发表时间: 2013-03
• 期刊: Oncology reports
• 影响因子: 4.2
• 作者: Sasada S;Miyata Y;Tsutani Y;Tsuyama N;Masujima T;Hihara J;Okada M
• 通讯作者: Okada M

Expression of HIF1α and GLUT1 correlates with FDG uptake on PET and tumor aggressiveness in different histologic subtypes of lung adenocarcinomas

HIF1α和GLUT1的表达与肺腺癌不同组织学亚型中PET上的FDG摄取和肿瘤侵袭性相关

• 发表时间: 2012
• 作者: Miyata Y;Furukawa T;Tsutani Y;Mimae T;Misumi K;Yoshiya T;Ibuki Y;Okada M;Miyata Y
• 通讯作者: Miyata Y

Expression of HIF1αand GLUT1 correlates with FDG uptake on PET and tumor aggressiveness in different histologic subtypes of lung adenocarcinomas

HIF1α和GLUT1的表达与肺腺癌不同组织学亚型中PET上的FDG摄取和肿瘤侵袭性相关

• 发表时间: 2012
• 作者: Miyata Y;Furukawa T;Tsutani Y;Mimae T;Misumi K;Yoshiya T;Ibuki Y;Okada M
• 通讯作者: Okada M