Direct injection treatment for intra-parenchymal spinal glioma
脊髓实质内胶质瘤直接注射治疗
基本信息
- 批准号:22591620
- 负责人:
- 金额:$ 2.41万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2010
- 资助国家:日本
- 起止时间:2010 至 2012
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
C6 is a glioblstoma cell originated from brain of a rat. The cells were treated by temozolomide (TMZ) in vitro for dose-response study, and the cell growth was definitely suppressed in 100μM of TMZ. And next, we evaluated that whether 100μM TMZ causes toxic effect or not to rat's brain parenchyma. No brain parenchymal damage was identified in the brain as far as inject-speed was kept in less than 0.25μl/minutes. First, C6 cells were implanted into subcutaneous in bilateral lumbar regions, and TMZ was injected directly into the tumor 3 days after the implantation of C6 cells. As a control, saline solution was injected into the tumor instead of TMZ. Tumor growth was suppressed in TMZ injected cases. And next, C6 cells were injected into the right brain sub-cortex, and TMZ was injected directly into the tumor 3 days after the implantation of C6 cells.Saline solution was injected into the tumor in control rats. Compared with control,TMZ-treated tumor showed much slower growth.
C6是一种起源于大鼠脑内的胶质母细胞瘤细胞。体外用替莫唑胺处理细胞进行量效关系研究,100μM的替莫唑胺对细胞生长有明显抑制作用。接下来,我们评估了100TMZ对大鼠脑实质是否有毒性作用。注射速度控制在0.25μL/分钟以下时,未发现脑实质损伤。先将C6细胞植入双侧腰部皮下,C6细胞移植后3天直接瘤内注射TMZ。作为对照,瘤体内注射生理盐水,而不注射TMZ。注射TMZ的患者肿瘤生长受到抑制。然后,将C6细胞注入右侧大脑皮质下,C6细胞移植后3d,肿瘤内直接注射TMZ,对照组肿瘤内注射生理盐水。与对照组相比,TMZ治疗组肿瘤生长明显减慢。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Glioblastomaに対する化学療法の効果とMGMT発現との相関
胶质母细胞瘤化疗效果与MGMT表达的相关性
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:Matsuno A;Katakami H;Okazaki R;Yamada S;Sasaki M;Nakaguchi H;Yamada SM;et al.;黒住和彦;市川智継;山田昌興
- 通讯作者:山田昌興
Skull base metastatic from follicular thyroid carcinoma : A report of two cases
滤泡性甲状腺癌颅底转移二例报告
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:Matsuno A;Katakami H;Okazaki R;Yamada S;Sasaki M;Nakaguchi H;Yamada SM;et al.
- 通讯作者:et al.
Intrathecal endoscopy to enhance the diagnosis of tethered cord syndrome.
鞘内内窥镜检查可增强脊髓栓系综合征的诊断。
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:Woods KR;Colohan AR;Yamada S;Yamada SM;Won DJ.
- 通讯作者:Won DJ.
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
YAMADA Shoko其他文献
YAMADA Shoko的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('YAMADA Shoko', 18)}}的其他基金
Construct an assessment model to prevent pain, agitation, and delirium from patients in intensive care unit
构建评估模型以预防重症监护病房患者的疼痛、躁动和谵妄
- 批准号:
26463303 - 财政年份:2014
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Pain Assessment Tool Development for ICU Patients with Difficulty in Verbal Communication.
为言语交流困难的 ICU 患者开发疼痛评估工具。
- 批准号:
23792583 - 财政年份:2011
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Reconstruction of Educational Reseearch in Developing countries: Integrated approach of area studies and development studies
发展中国家教育研究的重建:区域研究和发展研究的综合方法
- 批准号:
21252007 - 财政年份:2009
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Relation between consciousness level under sedation or experiences in ICU and postoperative delirium in ICU patients
ICU患者镇静状态下意识水平或ICU经历与术后谵妄的关系
- 批准号:
20791696 - 财政年份:2008
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
相似海外基金
Establishment of pathogenic mechanism based on the various epigemic alterations and analysis of drug resistance in malignant glioma
基于恶性胶质瘤多种表观改变及耐药分析的致病机制建立
- 批准号:
16K10761 - 财政年份:2016
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
MicroRNA regulating metabolic stress enhances therapeutic sensitivity in glioma
MicroRNA调节代谢应激提高神经胶质瘤的治疗敏感性
- 批准号:
15K19973 - 财政年份:2015
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Development of new anti-tumor therapy for malignant glioma using a drug incorporating polymeric micelle attached with a specific antibody for glioma cancer stem cell
使用附有针对神经胶质瘤干细胞的特异性抗体的聚合物胶束的药物开发针对恶性神经胶质瘤的新抗肿瘤疗法
- 批准号:
23390351 - 财政年份:2011
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Molecular biological research on the sensitivity for the treatment of GBM focused on the carcinogenic process
GBM治疗敏感性的分子生物学研究重点关注致癌过程
- 批准号:
22791224 - 财政年份:2010
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
The induction of autophagy in malignant glioma cells treated with natural compound
天然化合物处理恶性胶质瘤细胞自噬的诱导
- 批准号:
21791349 - 财政年份:2009
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
ドキソルビシンリポソームCED・テモゾロマイド全身投与併用による膠芽腫新規治療法
联合阿霉素脂质体 CED 和替莫唑胺全身给药治疗胶质母细胞瘤
- 批准号:
18791006 - 财政年份:2006
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Young Scientists (B)