Evaluation of neuroprotective efficacy by the regulation of microglial activation in models of spinal cord ischemia

尽管米诺环素已被证明在脑缺血模型中具有神经保护作用，但还没有关于米诺环素在脊髓缺血(SCI)模型中的作用的数据。在第一项研究中，我们研究了米诺环素对脊髓损伤大鼠模型的影响。在脊髓损伤前10分钟开始，从12小时开始，连续3天腹腔注射米诺环素。结果表明，米诺环素可改善后肢运动功能，减轻灰质和白质损伤。在第二项研究中，我们研究了缺血后给予米诺环素是否减轻了兔脊髓损伤后的后肢运动功能障碍和灰质和白质损伤。结果表明，脊髓损伤后1h开始应用米诺环素可改善兔后肢运动功能障碍，减轻脊髓灰质损伤。提示米诺环素可作为脊髓损伤神经保护的候选药物。

Although minocycline has been shown to have neuroprotective effects in models of cerebral ischemia, there have been no data available regarding the effects of minocycline in a model of spinal cord ischemia (SCI). In the first study, we investigated the effects of minocycline in a rat model of SCI. Minocycline was intraperitoneally administered for 3 days beginning at 12 hours before 10 minutes of SCI. The results indicated that minocycline administration improved hind-limb motor function and attenuated gray and white matter injury. In the second study, we investigate whether postischemic administration of minocycline attenuates hind-limb motor dysfunction and gray and white matter injuries after SCI in rabbits. The results indicated that minocycline administration beginning at 1 hour after reperfusion improved hind-limb motor dysfunction and attenuated gray matter injury after SCI in rabbits. These results indicated that minocycline can be a candidate for neuroprotection for SCI.