Tissue hormone determination and prostate cancer

前列腺组织中的雌激素浓度很低，即使用新发展的LC-MS/MS超灵敏分析方法也很难测定。在人体脂肪组织中发现了类固醇激素，包括活性雄激素和雄激素合成酶活性。这些结果表明，脂肪组织可能是前列腺癌雄激素合成的另一个来源，并可能通过刺激对其配体变得敏感的雄激素受体癌细胞而与CRPC的发展有关。

The concentration of estrogen in the prostate tissue was very little, that it was difficult to determine it even with a newly developed ultra-sensitive analytical method utilizing liquid chromatography-tandem mass spectrometry (LC-MS/MS). Steroid hormones including active androgens and androgen-synthetic enzyme activity were demonstrated in human adipose tissue. These results suggest that adipose tissue may be another source of androgen synthesis in prostate cancer and may be related to the development of CRPC by stimulating androgen receptor-bearing cancer cells, which become hypersensitive to its ligand.