Analysis of the regulation of androgen receptor by renin-angiotensin system in prostate cancer

我们通过体内外实验证实了肾素-血管紧张素系统具有调节前列腺癌细胞雄激素受体表达的潜力。此外，我们进行了一项临床研究，以证实血管紧张素II受体阻滞剂（ARB）是否会影响前列腺癌的发展，结果表明，ARB有可能通过AT 1受体抑制雄激素受体的表达。此外，临床研究显示，ARB治疗延迟了前列腺切除术后PSA复发患者的PSA升高。

We have confirmed that renin-angiotensin system have the potential to Regulate the expression of androgen receptor in prostate cancer cells via in vitro and in vivo experiment. Furthermore, we conducted a clinical study to confirm whether angiotensin II receptor blocker (ARB) would influence the development of prostate cancer .As a result, ARB has the potential to inhibit the expression of androgen receptor through AT1 receptor. Furthermore, clinical study revealed that ARB treatment delayed PSA risingin patients with PSA recurrence after prostatectomy.