Analysis of bioactive function of angiotensin II in prostate cancer

血管紧张素II(Ang-II)在控制血压和电解质/液体动态平衡方面发挥着重要的血管收缩作用，最近的研究表明，Ang-II是一种细胞因子，尤其是在心血管和基质细胞中作为生长因子发挥作用。此外，Ang-II在前列腺癌和间质细胞中的生理功能似乎相似。人们普遍认为Ang-II促进这两种细胞的生长，其受体阻滞剂(ARB)有可能通过AT1受体抑制多种癌细胞和肿瘤的生长。ARBS抑制细胞生长的机制被认为是抑制前列腺癌细胞内生长因子或细胞因子激活的信号转导系统，抑制血管生成。这项研究可能有助于前列腺癌的化学预防或药物发现。

Angiotensin II (Ang-II) plays a key role as a vasoconstrictor in controlling blood pressure and electrolyte/fluid homeostasis, and it has recently been shown that this peptide is a cytokine, especially acting as a growth factor in cardiovascular and stromal cells. In addition, the physiological function of Ang-II seems to be similar in prostate cancer and stromal cells. It is widely assumed that Ang-II facilitates the growth of both cells, and its receptor blockers (ARBs) have the potential to inhibit the growth of various cancer cells and tumors through the AT1 receptor. The mechanism of cell growth inhibition by ARBs has been considered to be suppression of the signal transduction systems activated by growth factors or cytokines in prostate cancer cells, and suppression of angiogenesis. This research may lead to develop the chemo-prevention or drug discovery of prostate cancer.