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Research for novel regulatory mechanisms by functional analysis of novel bioactive peptide and its receptor

Research for novel regulatory mechanisms by functional analysis of novel bioactive peptide and its receptor
通过新型生物活性肽及其受体的功能分析研究新型调控机制
批准号:
22790892
负责人:
MORI Kenji
金额:
$2.58万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

项目摘要

项目成果

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相关文献

中文摘要
翻译
通过电子筛选,鉴定出一种新的生物活性多肽。该多肽是由已知神经肽的前体蛋白通过差示蛋白分解处理而产生的。大鼠侧脑室注射多肽可引起血浆中特异性垂体激素浓度升高。观察到放射性标记多肽与大鼠脑切片的特异性结合。为了阐明一种新发现的多肽的生理作用,我们建立了只缺少这种多肽的小鼠。
英文摘要
A novel bioactive peptide was identified by in silico screening. This peptide was produced from a precursor protein of known neuropeptide by differential proteolytic processing. Intracerebroventricular administration of peptide to rats induced increase in plasma concentration of specific pituitary hormone. A specific binding of radiolabeled peptide to a section of rat brain was observed. To elucidate the physiological role of a newly identified peptide, mice lacking only this peptide were generated.
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会议论文
摂食調節におけるニューロメジンSとニューロメジンU
Neuromedin S 和 Neuromedin U 在喂养调节中的作用
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [森健二, 宮里幹也, 中原桂子, 村上昇, 寒川賢治]
通讯作者: 寒川賢治
DOI: 10.1677/joe-10-0081
发表时间: 2010-11
期刊: The Journal of endocrinology
影响因子: --
作者: [K. Nakahara;T. Katayama;K. Maruyama;T. Ida;K. Mori;M. Miyazato;K. Kangawa;N. Murakami]
通讯作者: K. Nakahara;T. Katayama;K. Maruyama;T. Ida;K. Mori;M. Miyazato;K. Kangawa;N. Murakami
ニューロメジンUとニューロメジンS
Neuromedin U 和 Neuromedin S
DOI: --
发表时间: 2007
期刊: ホルモンと臨床 881
影响因子: --
作者: [井田隆徳, 児島将康]
通讯作者: 児島将康
ニューロメジンSとその多様な機能
Neuromedin S 及其各种功能
DOI: 10.5983/nl2008jsce.37.124
发表时间: 2011
期刊: Comparative Endocrinology
影响因子: --
作者: [森健二, 森美和, 宮里幹也, 寒川賢治]
通讯作者: 寒川賢治
11
    Brain reactions during children's reading activities
    • 批准号:
      19K10978
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.25万
    • 财政年份:
      2019
    • 负责人:
      MORI Kenji
    • 依托单位:
    Studies on the biological regulatory mechanisms by a novel bioactive peptide, neuromedin U precursor-related peptide (NURP)
    Evaluation of the brain function during the listening of picture-book storytelling
    • 批准号:
      16K12145
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.66万
    • 财政年份:
      2016
    • 负责人:
      MORI Kenji
    • 依托单位:
    Studies on the regulatory mechanisms of physiological processes by newly identified bioactive peptide
    海外基金