Research for novel regulatory mechanisms by functional analysis of novel bioactive peptide and its receptor

通过新型生物活性肽及其受体的功能分析研究新型调控机制

• 批准号: 22790892
• 负责人: MORI Kenji
• 金额: $ 2.58万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790892/
• 关键词: 内分泌; 神経ペプチド; 生理活性ペプチド; 受容体

A novel bioactive peptide was identified by in silico screening. This peptide was produced from a precursor protein of known neuropeptide by differential proteolytic processing. Intracerebroventricular administration of peptide to rats induced increase in plasma concentration of specific pituitary hormone. A specific binding of radiolabeled peptide to a section of rat brain was observed. To elucidate the physiological role of a newly identified peptide, mice lacking only this peptide were generated.

通过计算机筛选鉴定出一种新型生物活性肽。该肽是通过差异蛋白水解加工从已知神经肽的前体蛋白产生的。向大鼠脑室内注射肽可引起特定垂体激素血浆浓度的增加。观察到放射性标记肽与大鼠大脑切片的特异性结合。为了阐明新鉴定的肽的生理作用，产生了仅缺乏该肽的小鼠。

项目成果

摂食調節におけるニューロメジンSとニューロメジンU

Neuromedin S 和 Neuromedin U 在喂养调节中的作用

• 发表时间: 2011
• 作者: 森健二;宮里幹也;中原桂子;村上昇;寒川賢治
• 通讯作者: 寒川賢治

Comparison of feeding suppression by the anorexigenic hormones neuromedin U and neuromedin S in rats.

• DOI: 10.1677/joe-10-0081
• 发表时间: 2010-11
• 期刊: The Journal of endocrinology
• 作者: K. Nakahara;T. Katayama;K. Maruyama;T. Ida;K. Mori;M. Miyazato;K. Kangawa;N. Murakami

ニューロメジンUとニューロメジンS

Neuromedin U 和 Neuromedin S

• 发表时间: 2007
• 期刊: ホルモンと臨床 881
• 作者: 井田隆徳;児島将康
• 通讯作者: 児島将康

Identification of the novel bioactive peptides dRYamide-1 and dRYamide-2, ligands for a neuropeptide Y-like receptor in Drosophila

• DOI: 10.1016/j.bbrc.2011.06.081
• 发表时间: 2011-07-15
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Ida, Takanori;Takahashi, Tomoko;Kojima, Masayasu
• 通讯作者: Kojima, Masayasu

ニューロメジンＳとその多様な機能

Neuromedin S 及其各种功能

• DOI: 10.5983/nl2008jsce.37.124
• 发表时间: 2011
• 期刊: Comparative Endocrinology
• 作者: 森健二;森美和;宮里幹也;寒川賢治
• 通讯作者: 寒川賢治