Exploration of signal transduction mechanism of TSLP aiming at developing a novel therapy for allergic disorders

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Thymic stromal lymphopoietin(TSLP) is a cytokine that plays an important role in the development of allergic inflammation. It was shown to activate human dendritic cells to promote Th2-type immune response. We examined the detailed signal transduction mechanism of TSLP. The multiple signal pathways activated by TSLP were selectively down-regulated by the Th1-inducing agents such as TLR ligands. Furthermore, we successfully established a cell line that demonstrates activation of the similar signal pathways by TSLP to those in dendritic cells. This cell line will be of great help in analyzing biochemical properties of the TSLP signal transduction