The analysis of serum cytokine and transcription factor level on the pathophysiology of neonatal asphyxia and intraventricular hemorrhage of extremely low birth weight infant

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We analyzed cytokine levels in peripheral blood from 5 full-term and 3 preterm infants with neonatal asphyxia and those from 5 full-term and 4 preterm infants without neonatal asphyxia on 0,1,2,3 day of life. We found that inflammatory cytokines were at higher level in the former group and decreased over time.In peripheral blood from 15 extremely low birth weight (ELBW) infants who received indomethacin for preventing intraventricular hemorrhage and 11 ELBW who did not receive indomethacin, we analyzed cytokine profiles on 0,1,2,3,7,14 day of life. Inflammatory cytokines are at lower levels and decreased over time in the former group than the later group. It suggests that indomethacin inhibits production of these inflammatory cytokines, and preventing a intraventricular hemorrhage.