Mechanisms underlying effects of BDNF and antidepressants on microglia ; Possible role of TRPC channels(MIZOGUCHI YOSHITO)

BDNF 和抗抑郁药对小胶质细胞影响的潜在机制；

• 批准号: 22791128
• 负责人: MIZOGUCHI Yoshito
• 金额: $ 2.5万
• 依托单位: Saga University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791128/
• 关键词: うつ病; BDNF; ミクログリア; 神経炎症; 薬理学

In rodent microglial cells, sustained activation of SOCE, possibly mediated by TRPC3 channels, occurred after brief BDNF application and contributed to the maintenance of sustained[ Ca^<2+>] i elevation. BDNF acutely upregulates the surface expression of TRPC3 channels in rodent microglia. In addition, RT-PCR and immunocytochemical techniques revealed that TRPC3 channels are highly expressed in rodent microglial cells.

在啮齿动物小胶质细胞中，短暂应用BDNF后，SOCE持续激活，可能由TRPC 3通道介导，并有助于维持持续的[ Ca^2+] i升高。BDNF急性上调啮齿类小胶质细胞TRPC 3通道的表面表达此外，RT-PCR和免疫细胞化学技术显示TRPC 3通道在啮齿动物小胶质细胞中高度表达。

项目成果

SSRI potentiates BDNF-induced microglial intracellular Ca^<2+> elevation Society for Neuroscience

SSRI 增强 BDNF 诱导的小胶质细胞内 Ca^2 > 升高

• 发表时间: 2011
• 作者: Mizoguchi Y;et al;Mizoguchi Y et al
• 通讯作者: Mizoguchi Y et al

Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: Implication for antioxidative psychotropic actions via microglia

• DOI: 10.1016/j.schres.2011.03.019
• 发表时间: 2011-07-01
• 期刊: SCHIZOPHRENIA RESEARCH
• 影响因子: 4.5
• 作者: Kato, Takahiro A.;Monji, Akira;Kanba, Shigenobu
• 通讯作者: Kanba, Shigenobu

Baseline saliva level of 3-methoxy-4-hydroxyphenylglycole (MHPG) associates with a consequent cognitive decline in non-demented elderly subjects Three-years follow-up study

3-甲氧基-4-羟基苯基乙二醇 (MHPG) 的基线唾液水平与非痴呆老年受试者随后的认知能力下降相关三年随访研究

• DOI: 10.1016/j.psychres.2011.07.013
• 发表时间: 2012
• 期刊: Psychiatry Research
• 影响因子: 11.3
• 作者: Itaru Watanabe;Guang Y. Li;Yoshiomi Imamura;Hiromitsu Nabeta;Yutaka Kunitake;Hironobu Ishii;Masanori Haraguchi;Yuzo Furukawa;H. Tateishi;Naoki Kojima;Yoshito Nizoguchi;S. Yamada
• 通讯作者: S. Yamada