Brain aromatase and aggression: Human PET study

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A PET probe for aromatase imaging named [^<11>C]cetrozole was newly developed in order to measure quantitatively aromatase in human brain. The pharmacokinetics and dynamics of [^<11>C]cetrozole were defined in animal experiments, and then the PET probe was administered in living human. Healthy subjects were asked to answer questionnaires to measure their aggression, temperament and character. The regression analysis showed positive correlation between aromatase level in the thalamus and the score for aggression and also positive correlation between aromatase level in the hypothalamus and the score for empathy. This study may clarify the relationship between aromatase and human character, emotion, or mood.