Brain aromatase and aggression: Human PET study

大脑芳香酶和攻击性：人类 PET 研究

• 批准号: 22791155
• 负责人: TAKAHASHI Kayo
• 金额: $ 2.58万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791155/
• 关键词: aromatase; human; PET; aggression; temperament and character; estrogen; emotion; hypothalamus; thalamus; amygdala; Aromatase; Emotion; Estrogen

A PET probe for aromatase imaging named [^<11>C]cetrozole was newly developed in order to measure quantitatively aromatase in human brain. The pharmacokinetics and dynamics of [^<11>C]cetrozole were defined in animal experiments, and then the PET probe was administered in living human. Healthy subjects were asked to answer questionnaires to measure their aggression, temperament and character. The regression analysis showed positive correlation between aromatase level in the thalamus and the score for aggression and also positive correlation between aromatase level in the hypothalamus and the score for empathy. This study may clarify the relationship between aromatase and human character, emotion, or mood.

为了<11>定量测定人脑中的芳香化酶，我们研制了一种新的芳香化酶PET显像探针[^ C]西曲唑。在<11>动物实验中确定了[^ C]西曲唑的药代动力学和动力学，然后将PET探针施用于活体人体。健康受试者被要求回答问卷，以测量他们的攻击性，气质和性格。回归分析显示丘脑芳香化酶水平与攻击性得分呈正相关，下丘脑芳香化酶水平与共情得分呈正相关。本研究可能有助于阐明芳香化酶与人的性格、情绪或心境的关系。

项目成果

^<11>C-Labeled cetrozole and its analogs : an excellent PET probe for aromatase in brain

^<11>C标记的赛曲唑及其类似物：一种优秀的脑内芳香酶PET探针

• 发表时间: 2010
• 作者: Takahashi;K;Takahashi K;Takahashi K
• 通讯作者: Takahashi K

Aromatase imaging for emotional and affective disorders

芳香酶成像治疗情绪和情感障碍

• 发表时间: 2011
• 作者: Takahashi K;Hosoya T;Takashima T;Tanaka M;Ishii A;Nakatomi Y;Tazawa S;Takahashi K;Doi H;Watanabe Yu;Wada Y;Suzuki M;Onoe H;Watanabe Y;高橋佳代
• 通讯作者: 高橋佳代

Imaging brain aromatase in human with [^<11>C]cetrozole

使用[^11C]cetrozole对人脑芳香酶进行成像

• 发表时间: 2012
• 作者: Takahashi K;Hosoya T;Takashima T;Tanaka M;Ishii A;Nakatomi Y;Tazawa S;Takahashi K;Doi H;Watanabe Yu;Wada Y;Suzuki M;Onoe H;Watanabe Y
• 通讯作者: Watanabe Y

^<11>C-Labeled cetrozole and its analogs : excellent PET probes for aromatase.

^<11>C-标记的赛曲唑及其类似物：优异的芳香酶PET探针。

• 发表时间: 2010
• 作者: Takahashi;K;Takahashi K
• 通讯作者: Takahashi K

新規aromatase イメージングPETプローブ

新型芳香酶成像 PET 探针

• 发表时间: 2011
• 作者: 高橋佳代;細谷孝充;尾上嘉代;長田浩子;土居久志;和田康弘;高島忠之;田村泰久;渡辺由美子;田中雅彰;石井聡;鈴木正昭;尾上浩隆;渡辺恭良
• 通讯作者: 渡辺恭良