Establishment of the treatment and pathophysiology based on the susceptibility gene in lumbar disc disease.

与对照组相比，TG组小鼠髓核组织中的藏红素O染色明显减弱。MRI分析显示TG小鼠有明显的退变，提示腰椎T2加权成像的强度降低。将不稳定性引入CILP Tg小鼠颈椎，建立颈椎间盘退变及突出症动物模型。组织学分析提示，间盘退变的进展与转化生长因子-β信号的调控有关。CILP有可能促进椎间盘退变。

Safranin O staining in intervertebral disc were significantly decreased in Nucleus pulposus tissues of Tg mice compared to controls. MRI analysis indicated obvious progression of degenerative intervertebral discs in Tg mice, which suggested reduction of the intensity of lumbar T2 weighted MR imaging. The cervical intervertebral disc degeneration and hernia models were established by introducing instability into cervical vertebrate of CILP Tg mice. The histological analysis suggested that progression of intervertebral disc degeneration and regulation of TGF-βsignaling. There may be a possibility that CILP enhance intervertebral disc degeneration.