Development of novel intravesical agents for the treatment of refractory superficial bladder cancer

开发治疗难治性浅表性膀胱癌的新型膀胱灌注药物

• 批准号: 22791473
• 负责人: WATANABE Masami
• 金额: $ 2.5万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791473/
• 关键词: 膀胱癌; 遺伝子治療; 抗癌免疫; 分化; 癌

Bladder cancer is one of the most common urogenital malignancies. The intravesical instillation of anti-cancer agent is an attractive strategy to treat a superficial lesion or floating/disseminated cancer cells after transurethral operation. An adenovirus carrying REIC/Dkk-3, a tumor suppressor gene,(Ad-REIC) exhibits cancer-specific apoptotic effects in various types of cancer cells. In this study, we demonstrated that the intravesical instillation of Ad-REIC could be an attractive therapeutic method for the treatment of human bladder cancer.

膀胱癌是泌尿生殖系统最常见的恶性肿瘤之一。膀胱内灌注抗癌药物是治疗经尿道手术后浅表病变或漂浮/播散癌细胞的一种有吸引力的策略。携带肿瘤抑制基因REIC/Dkk-3的腺病毒（Ad-REIC）在各种类型的癌细胞中表现出癌症特异性凋亡效应。在这项研究中，我们证明了膀胱灌注Ad-REIC可能是一种有吸引力的治疗方法，用于治疗人膀胱癌。

项目成果

REIC/Dkk-3 gene therapy

REIC/Dkk-3基因治疗

• 发表时间: 2011
• 作者: Watanabe M;Kaku H;Huang P;Kumon H;Nasu Y
• 通讯作者: Nasu Y

Tumor growth and metastasis suppression by Glipr1 gene-modified macrophages in a metastatic prostate cancer model.

• DOI: 10.1038/gt.2011.51
• 发表时间: 2011-10
• 期刊: Gene therapy
• 影响因子: 5.1

Suicide gene and immuno gene therapy for prostate cancer

前列腺癌的自杀基因和免疫基因治疗

• 发表时间: 2011
• 作者: Nasu Y;Sasaki K;Kumon H;Kaku H;Watanabe M
• 通讯作者: Watanabe M

遺伝子発現を上昇させるシステム及び該システムを保持したベクター

增加基因表达的系统和携带该系统的载体

• 发表时间: 2009

Preclinical safety and efficacy of in situ REIC/Dkk-3 gene therapy for prostate cancer.

• DOI: 10.18926/amo/48076
• 发表时间: 2012-03
• 期刊: Acta medica Okayama
• 影响因子: 0.5
• 作者: Keiichiro Kawauchi;Masami Watanabe;H. Kaku;Peng Huang;Kasumi Sasaki;M. Sakaguchi;K. Ochiai;N. Huh;Y. Nasu;H. Kumon