Development of novel intravesical agents for the treatment of refractory superficial bladder cancer

膀胱癌是最常见的泌尿生殖系统恶性肿瘤之一。膀胱内注入抗癌药是治疗经尿路手术后浅表病变或肿瘤细胞漂浮/扩散的一种有吸引力的策略。携带肿瘤抑制基因reic/DKK-3的重组腺病毒(Ad-reic)在不同类型的癌细胞中表现出肿瘤特异性的凋亡效应。在本研究中，我们证明了腺苷在膀胱癌的治疗中可能是一种很有吸引力的治疗方法。

Bladder cancer is one of the most common urogenital malignancies. The intravesical instillation of anti-cancer agent is an attractive strategy to treat a superficial lesion or floating/disseminated cancer cells after transurethral operation. An adenovirus carrying REIC/Dkk-3, a tumor suppressor gene,(Ad-REIC) exhibits cancer-specific apoptotic effects in various types of cancer cells. In this study, we demonstrated that the intravesical instillation of Ad-REIC could be an attractive therapeutic method for the treatment of human bladder cancer.