Radiation-induced long-lived radicals causing mutation and carcinogenesis
Radiation-induced long-lived radicals causing mutation and carcinogenesis
批准号:
16101002
负责人:
WATANABE Masami
金额:
$64.81万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2004
资助国家:
日本
项目状态:
已结题
起止时间:
2004 至 2008
中文摘要
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英文摘要
放射線を照射された細胞に複数の長寿命ラジカル(LLR^*)が誘導されることがわかった。その代表的なものが、システイン残基を持つタンパク質に生じたスルフィニルラジカル(R-CH2-SO・)およびセミキセノンラジカルである。これらは、放射線被ばく後、1時間~10時間の間にミトコンドリアで誘導され、細胞内の高分子タンパクをゆっくりラジカル化することによって、細胞の様々な高度機能障害を生じさせることが明らかとなった。
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DOI:
10.1269/jrr.08109
发表时间:
2009-03
期刊:
Journal of radiation research
影响因子:
2
作者:
[Tomohiro Yoshikawa;G. Kashino;K. Ono;M. Watanabe]
通讯作者:
Tomohiro Yoshikawa;G. Kashino;K. Ono;M. Watanabe
DOI:
10.1667/rr3542.1
发表时间:
2006-05-01
期刊:
RADIATION RESEARCH
影响因子:
3.4
作者:
[Suzuki, K, Okada, H, Watanabe, M]
通讯作者:
Watanabe, M
DOI:
10.1016/j.mrfmmm.2005.08.007
发表时间:
2006-02-22
期刊:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
影响因子:
2.3
作者:
[Suzuki, M, Tsuruoka, C, Watanabe, M]
通讯作者:
Watanabe, M
DOI:
10.1016/j.jplph.2004.11.014
发表时间:
2005-06-01
期刊:
JOURNAL OF PLANT PHYSIOLOGY
影响因子:
4.3
作者:
[Ishikawa, A, Kitamura, Y, Watanabe, M]
通讯作者:
Watanabe, M
Evaluation of the potential of hexamethylenetetramineas a combined agent with gamma-ray irradiation and cisplatin treatment in vivo, compared with tirapazamine
与替拉扎明相比,评估六亚甲基四胺作为伽马射线照射和顺铂体内治疗联合用药的潜力
DOI:
--
发表时间:
2009
期刊:
British J Radiol Jan 19(Epub ahead of print)
影响因子:
--
作者:
[Masunaga S, Tano K, Watanabe M, Kashino G, Suzuki M, Kinashi Y, Ono K, Nakamura J]
通讯作者:
Nakamura J
共 48 条
Development of novel intravesical agents for the treatment of refractory superficial bladder cancer
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批准号:22791473
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.5万
-
财政年份:2010
-
负责人:WATANABE Masami
-
依托单位:
Cell transformation route and the developmental mechanics which assumed chromosomal aneuploidy an origin
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批准号:21310036
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$12.15万
-
财政年份:2009
-
负责人:WATANABE Masami
-
依托单位:
Examination for detection of early glaucoma with ON- and OFF-delays of subjects with normal and glaucomatous eyes
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批准号:19592051
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.0万
-
财政年份:2007
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负责人:WATANABE Masami
-
依托单位:
Functional Recovery of Vision with Axonal Regeneration in Crushed Optic Nerve
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批准号:16591780
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2004
-
负责人:WATANABE Masami
-
依托单位:
RADIATION-INDUCED LONG LIVED RADICALS CAUSING MUTATION AND TRANSFORMATION
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批准号:13480171
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.6万
-
财政年份:2001
-
负责人:WATANABE Masami
-
依托单位:
PROTECTION FROM DEATH OF AXOTOMIZED RETINAL GANGLION CELLS AND PROMOTION OF THEIR AXONAL REGENERATION
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批准号:12671733
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.37万
-
财政年份:2000
-
负责人:WATANABE Masami
-
依托单位:
AN IMPORTANT ROLE OF GENETICAL INSTABILITY IN RADIATION CARCINOGENESIS
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批准号:09480126
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$3.84万
-
财政年份:1997
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负责人:WATANABE Masami
-
依托单位:
Genetical Instability induced by Low Doses of Radations
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批准号:06454640
-
项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.67万
-
财政年份:1994
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负责人:WATANABE Masami
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依托单位:
Research on Regeneration of the Optic Nerve and Functional Recovery of Retinal Ganglion Cells with Regenerated Axons
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批准号:03670841
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项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.02万
-
财政年份:1991
-
负责人:WATANABE Masami
-
依托单位:
海外基金