Research of Cotylenin A functions in retinoblastoma cells

Cotylenin A在视网膜母细胞瘤细胞中的功能研究

• 批准号: 22791649
• 负责人: KASHIWAGI Yoshiko
• 金额: $ 2.5万
• 依托单位: Yonezawa women's junior college (2011)Yamagata University (2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791649/
• 关键词: コチレニン A; 網膜芽細胞腫; 神経節細胞; 抗腫瘍; 神経保護; コチレニンA; PAX6

We found that Cotyelenin A is a potent inhibitor of cell proliferation and apoptosis, and it changes tumor characteristics in retinoblastoma cell lines. Differences in the effect of Cotyelenin A on ocular retinoblastoma tumors and metastatic tumours were observed. However, we could not detect the function of nerves protection in rat retina ganglion cells (RGC5).

我们发现Cotyelenin A是一种有效的细胞增殖和凋亡抑制剂，它改变了视网膜母细胞瘤细胞系的肿瘤特性。观察到Cotyelenin A对眼视网膜母细胞瘤肿瘤和转移性肿瘤的作用的差异。但在大鼠视网膜神经节细胞（RGC5）中未检测到神经保护作用。

项目成果

Cotylenin A inhibits cell proliferation and induces apoptosis and PAX6 mRNA transcripts in retinoblastoma cell lines.

Cotylenin A 抑制视网膜母细胞瘤细胞系中的细胞增殖并诱导细胞凋亡和 PAX6 mRNA 转录。

• 发表时间: 2010
• 期刊: Mol Vis.
• 作者: Kashiwagi Y;Kato N;Sassa T;Nishitsuka K;Yamamoto T;Takamura H;Yamashita H.
• 通讯作者: Yamashita H.