The role of Wnt signaling in the articular surface cells functions.

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The surface of articular cartilage is covered with unique cells called superficial cells. To keep maintaining articular function under the loaded circumstances, it is important to activate superficial cells. The aim of this study is to investigate the characteristics of superficial cells, and the pathological and recovery mechanisms in articular cartilage injuries. This study found that the superficial cells had undifferentiated chondro progenitor cell-like properties, that was controlled by Wnt/β-catenin signaling using gain-and loss of function of β-catenin model mice.