Effective of a novel cholesterol-bearing pullulan nanogel membrane for guided bone regeneration
Effective of a novel cholesterol-bearing pullulan nanogel membrane for guided bone regeneration
批准号:
22791925
负责人:
KOBAYASHI Hiroshi
金额:
$2.16万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
Cholesterol-bearing pullulan(CHP) nanogel is a synthetic degradable biomaterial for drug delivery with high biocompatibility. The purpose of this study was to evaluate the effects of the CHP nanogel membrane in guided bone regeneration(GBR). As a result of micro-CT analysis, new bone formation in terms of bone volume was higher in the nanogel group than in the control or collagen groups at 2 and 4 weeks. Histologically, new bone formation in CHP nanogel was prominent at 2 and 4 weeks compared with the other two groups. Notably, newly-formed bone in the CHP nanogel group was mature bone. The results of this study suggest that CHP nanogel membrane would be potentially effective as a GBR membrane.
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DOI:
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发表时间:
2011
期刊:
影响因子:
--
作者:
[Takayuki Miyahara, Hiroshi Kobayashi, Kazunari Akiyoshi, Shohei Kasugai]
通讯作者:
Shohei Kasugai
DOI:
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发表时间:
2011
期刊:
影响因子:
--
作者:
[Takayuki Miyahara, Warunee Pluemsakunthai, Myat Nyan, Asako Shimoda, HiroshiKobayashi, Yuki Shimizu, Tatsuya Fujimori, Makoto Shiota, Kazunari Akiyoshi, ShoheiKasugai]
通讯作者:
ShoheiKasugai
新規GBR用ナノゲルクロスリンキングメンブレン-ラット頭蓋骨欠損モデルにおけるドライタイプとウェットタイプの骨治癒比較評価
新型GBR纳米凝胶交联膜——大鼠颅骨缺损模型干式和湿式骨愈合的比较评价
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[宮原宇将, 永山友子, 小林裕史, 黒田真司, 春日井昇平]
通讯作者:
春日井昇平
Early bone regeneration by novel nanogel cross linking membrane.
通过新型纳米凝胶交联膜进行早期骨再生。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Miyahara T, Nyan M, Shimoda A, Hao J, Rodoriguez R, Kobayashi H, Kuroda S, Shiota M, Akiyoshi K, Kasugai K.]
通讯作者:
Kasugai K.
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