Endometriosis-associated ovarian carcinogenesis induced by iron-dependent oxidative stress

铁依赖性氧化应激诱导子宫内膜异位症相关卵巢癌发生

• 批准号: 23390391
• 负责人: KOBAYASHI Hiroshi
• 金额: $ 12.23万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390391/
• 关键词: 子宮内膜症; 癌化; 卵巣癌; 酸化ストレス; 鉄; 卵巣がん; 細胞周期調節

The aim of the present study is to describe genomic instability, genetic polymorphisms and their haplotype, epigenetic alterations associated with endometriosis predisposition, and the key factors that have been linked to endometriosis-related ovarian neoplasms. Retrograde menstruation leads to iron overload, which facilitates the accumulation of somatic mutations through a Fenton reaction-mediated oxidative stress. There seems to be at least three spatiotemporally distinct phases of endometriosis development: The initial phase of genetic background inherited from parents would be followed by the second big wave of epigenetic modifications in the female offspring and the final phase of the iron overload that is subject to dynamic modulation later in life. The dramatic regulation of endometriosis susceptibility genes may come from a mechanism responsible for epigenetic and genetic mutations based on the microenvironmental changes.

本研究的目的是描述基因组不稳定性，遗传多态性及其单倍型，与子宫内膜异位症易感性相关的表观遗传学改变，以及与子宫内膜异位症相关的卵巢肿瘤相关的关键因素。逆行性月经导致铁超载，通过芬顿反应介导的氧化应激促进体细胞突变的积累。子宫内膜异位症的发展似乎至少有三个时空上不同的阶段：从父母遗传的遗传背景的初始阶段，随后是女性后代的第二波表观遗传修饰，以及铁过载的最后阶段，这是在以后的生活中受到动态调节。子宫内膜异位症易感基因的显著调节可能来自于基于微环境变化的表观遗传和基因突变机制。

项目成果

Risk of carcinoma in women with ovarian endometrioma.

• DOI: 10.2741/e267
• 发表时间: 2011
• 期刊: Frontiers in bioscience
• 作者: Hiroshi Kobayashi;Hirotaka Kajihara;Yoshihiko Yamada;Y. Tanase;S. Kanayama;N. Furukawa;T. Noguchi;S. Haruta;S. Yoshida;K. Naruse;T. Sado;H. Oi

子宮内膜症におけるCD44v9の免疫組織学的検討

CD44v9在子宫内膜异位症中的免疫组织化学研究

• 发表时间: 2013
• 作者: 植栗千陽;重富洋志;重光愛子;棚瀬康仁;春田祥治;金山清二;川口龍二;吉田昭三;古川直人;大井豪一;小林 浩;島田啓司;小西 登;須藤 保
• 通讯作者: 須藤 保

子宮内膜症性卵巣嚢胞が癌化している可能性を判定するためのデータ取得方法, およびその診断装置

用于确定子宫内膜异位卵巢囊肿癌变可能性的数据采集方法和诊断装置

• 发表时间: 2014

Uterine metastasis of lobular breast cancer during adjuvant letrozole therapy.

小叶乳腺癌辅助来曲唑治疗期间的子宫转移。

• DOI: 10.3109/01443615.2012.721407
• 发表时间: 2013
• 期刊: J Obstet Gynaecol
• 影响因子: 1.3
• 作者: Komeda S;Furukawa N;Kasai T;Washida A;Kobayashi H.
• 通讯作者: Kobayashi H.

Modulation of estrogenic action in clear cell carcinoma of the ovary

卵巢透明细胞癌中雌激素作用的调节

• 发表时间: 2012
• 期刊: Exp Ther Med.
• 作者: Tanase Y;Yamada Y;Shigetomi H;Kajihara H;Oonogi A;Yoshizawa Y;Furukawa N;Haruta S;Yoshida S;Sado T;Oi H;Kobayashi H.
• 通讯作者: Kobayashi H.