Research of the implantation method of the mixture of growth factor to increase the amount of periodontal tissue regeneration of horizontal bone defect

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This study investigated the effect of the combination of BMP and FGF, and the effect of structure of carrier used when the growth factor was implanted with the aim of increase of periodontal regeneration. A tunnel pipe structure having an inner diameter of 300μm induced an increase in cells and blood vessels derived from the residual bone into carrier and the bone defects, and that the amount of the bone regeration increased. This studysuggested that the structure to conduct the vessel invasion was important. Additionally, the new bone formation and cementum formation of the multi-layer implantation method consisting of both BMP-2-containing carrier and bFGF-2-containing carrier were larger than that of the complex implantation method of BMP-2 and bFGF-2 and BMP-2 or bFGF-2 only implantation method. The aberrant healing like ankylosis was inhibited, too. From the above results, thisstudy suggested that implantation method of the multi-layer using both BMP-2-containingcarrier and bFGF-2-containing carrier could enhance periodontal regeneration.