Research of the implantation method of the mixture of growth factor to increase the amount of periodontal tissue regeneration of horizontal bone defect

生长因子混合物植入法增加水平骨缺损牙周组织再生量的研究

• 批准号: 22792078
• 负责人: SAITO Emiko
• 金额: $ 2.58万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22792078/
• 关键词: 歯周外科学; BMP; ｂＦＧＦ-2; 水平性骨欠損; 多層移植法; 二層移植法; 歯周組織再生; bone morphogenetic protein; basic fibroblast growth factor; ハニカム構造; βTCP; bFGF

This study investigated the effect of the combination of BMP and FGF, and the effect of structure of carrier used when the growth factor was implanted with the aim of increase of periodontal regeneration. A tunnel pipe structure having an inner diameter of 300μm induced an increase in cells and blood vessels derived from the residual bone into carrier and the bone defects, and that the amount of the bone regeration increased. This studysuggested that the structure to conduct the vessel invasion was important. Additionally, the new bone formation and cementum formation of the multi-layer implantation method consisting of both BMP-2-containing carrier and bFGF-2-containing carrier were larger than that of the complex implantation method of BMP-2 and bFGF-2 and BMP-2 or bFGF-2 only implantation method. The aberrant healing like ankylosis was inhibited, too. From the above results, thisstudy suggested that implantation method of the multi-layer using both BMP-2-containingcarrier and bFGF-2-containing carrier could enhance periodontal regeneration.

本研究探讨了BMP和FGF的组合的效果，以及生长因子植入时所使用的载体结构的影响，目的是增加牙周再生。内径为300μm的隧道管结构诱导从残余骨衍生的细胞和血管增加到载体和骨缺损，并且骨再生量增加。本研究提示，引导血管侵入的结构是重要的。含BMP-2载体和bFGF-2载体的多层植入方法的新骨形成和牙骨质形成大于BMP-2和bFGF-2的复合植入方法和仅BMP-2或bFGF-2的植入方法。关节强直等畸形愈合也受到抑制。本研究结果提示，含BMP-2载体和bFGF-2载体的多层种植方法可促进牙周组织再生。

项目成果

rhBMP-2の担体に感温性ゲルを移植した場合の硬組織形成

热敏凝胶植入rhBMP-2载体上形成硬组织

• 发表时间: 2010
• 作者: 齋藤彰;齋藤恵美子
• 通讯作者: 齋藤恵美子

Effect of tunnel pipe structure of bone grafts onregeneration.

骨移植隧道管结构对再生的影响。

• 发表时间: 2010
• 作者: Akira Saito;Emiko Saito;Yoshinori Kuboki;Yoshitaka Yoshimura;Dairo Takahashi;Yoshiyuki Honma;Hiroko Takita;Mariko Takayama;Ryohei Handa ,Keishi Honma;Noboru Ohata
• 通讯作者: Noboru Ohata

歯牙移植後の付着様式に与えるエムドゲイン塗布と組織培養の影響

Emdogain应用和组织培养对牙移植后附着模式的影响

• 发表时间: 2011
• 作者: 加藤剛士;齋藤彰;齋藤恵美子;他2名
• 通讯作者: 他2名

Effect of tunnel pipe structure of bone grafts on periodontal regeneration infurcation class III defects.

骨移植隧道管结构对牙周炎Ⅲ类缺损再生的影响。

• 发表时间: 2011
• 作者: Akira Saito;Emiko Saito;Dairo Takahashi;Fumihiko Yuge;Tsuyoshi Kato;Yoshiyuki Honma;Noboru Ohata
• 通讯作者: Noboru Ohata

Bone and vascular formation by a beta-TCP with random-tunnel structure in furcation class III defects

具有随机隧道结构的 β-TCP 在分叉 III 类缺陷中形成骨和血管

• 发表时间: 2010
• 作者: Emiko SAITO;Akira SAITO
• 通讯作者: Akira SAITO