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The Dynamic mechanism of phagocytosis of apoptotic cells

The Dynamic mechanism of phagocytosis of apoptotic cells
凋亡细胞吞噬的动力学机制
批准号:
22790210
负责人:
HANAYAMA Rikinari
金额:
$2.58万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
Apoptotic cells are engulfed by macrophages by recognizing phosphatidylserine (PS). We found that Tim4 receptor on macrophages tethers apoptotic cells to macrophages by binding PS, and MFG-E8 secreted from macrophages binds to PS and stimulates the engulfment by binding to integrin on macrophages.
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会议论文
死細胞の除去とその疾患
去除死亡细胞及其疾病
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Aritomi S, Wagatsuma H, Numata T, Uriu Y, Nogi Y, Mitsui A, Konda T, Mori Y, & Yoshimura M, 魏范研, 華山力成]
通讯作者: 華山力成
DOI: 10.1128/mcb.05993-11
发表时间: 2012-01-01
期刊: MOLECULAR AND CELLULAR BIOLOGY
影响因子: 5.3
作者: [Toda, Satoshi, Hanayama, Rikinari, Nagata, Shigekazu]
通讯作者: Nagata, Shigekazu
The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc.
天使综合症蛋白 Ube3A 通过泛素化 arc 来调节突触发育。
DOI: 10.1016/j.cell.2010.01.026
发表时间: 2010-03-05
期刊: Cell
影响因子: 64.5
作者: [Greer PL, Hanayama R, Bloodgood BL, Mardinly AR, Lipton DM, Flavell SW, Kim TK, Griffith EC, Waldon Z, Maehr R, Ploegh HL, Chowdhury S, Worley PF, Steen J, Greenberg ME]
通讯作者: Greenberg ME
Elucidation of pathology caused by heterolysis and development of its visualization method using MRI
  • 批准号:
    16K15231
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $2.33万
  • 财政年份:
    2016
  • 负责人:
    HANAYAMA Rikinari
  • 依托单位:
海外基金