Application of enzymatically gellable gelatin derivative to peritoneal dissemination treatment

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We evaluated the possibility of gelatin derivative possessing phenolic hydroxyl moieties gellable via a horseradish peroxidase-catalyzed reaction as a candidate for controlled release of anti-cancer drugs for the treatment of peritoneal dissemination. Our studies revealed that the hydrogel was not suitable for the purpose. Therefore, we attempted to develop novel biodegradable and in situ gellable hydrogels. The promising hydrogel we developed in this study was the derivative of amylopectin. The aqueous solution of the amylopectin derivative possessing phenolic hydroxyl moieties could be gellable through the horseradish peroxidase-catalyzed reaction. An attractive property of the hydrogel was the degradability in the presence of serum. In addition, we could develop a novel hydrogelation process triggered by glucose using glucose oxidase for supplying hydrogen peroxide for the hydrogelation process.