Analysis of crosstalk between DNA repair and gene expression control

本研究的目的是研究DNA修复因子与转录因子之间的串扰，以便在分子水平上了解DNA修复系统缺陷引起的遗传疾病。结果表明，参与核苷酸切除修复的XPG与一些转录因子以及一般转录因子TFIIH相互作用，XPG的转录功能与XP-G患者的临床特征密切相关。

The aim of this study is to investigate the crosstalk between DNA repair factors and transcription factors so that genetic disorders caused by defects in DNA repair system can be understood at a molecular level. The results show that XPG, which is involved in nucleotide excision repair, interacts with some transcription factors as well as general transcription factor TFIIH, and that the function of XPG in transcription is closely related to clinical features found in XP-G patients.