Molecular mechanisms of left-right asymmetric morphogenesis in visceral organs and limb
Molecular mechanisms of left-right asymmetric morphogenesis in visceral organs and limb
批准号:
22770215
负责人:
SHIRATORI Hidetaka
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
About left-right asymmetric morphogenesis in visceral organs and limb, I discovered the following molecular mechanisms:(1)Endocardium, which receives Fgf signals, has important role in morphogenesis of heart outflow tract.(2)Morphogenesis of heart outflow tract involves several Fgf factors in addition to Fgf10.(3)Expression of Pitx2is initiated in left lateral plate mesoderm, and also begins at paraxial mesoderm cells in the limb bud.(4)Cell proliferation rate of Pitx2-expressing cells in dorso-ventral region of left limb is different between wild type and Pitx2mutant embryos. Pitx2 inhibits cell proliferation in these cells.
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DOI:
10.1016/j.ydbio.2011.03.009
发表时间:
2011-05-15
期刊:
Developmental biology
影响因子:
2.7
作者:
[Kawasumi A, Nakamura T, Iwai N, Yashiro K, Saijoh Y, Belo JA, Shiratori H, Hamada H]
通讯作者:
Hamada H
DOI:
10.1002/dvdy.22492
发表时间:
2011-01-01
期刊:
DEVELOPMENTAL DYNAMICS
影响因子:
2.5
作者:
[Furtado, Milena B., Biben, Christine, Harvey, Richard P.]
通讯作者:
Harvey, Richard P.
器官の左右非対称性形成の分子機構
器官左右不对称形成的分子机制
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[原口徳子、荒神尚子、小坂田裕子、糀谷知子、小林昇平、中野めぐみ、舛本寛、Larionov, V.、Earnshaw, W. C. 平岡泰, 白鳥秀卓]
通讯作者:
白鳥秀卓
DOI:
10.1038/ncomms1624
发表时间:
2012-01-01
期刊:
NATURE COMMUNICATIONS
影响因子:
16.6
作者:
[Shinohara, Kyosuke, Kawasumi, Aiko, Hamada, Hiroshi]
通讯作者:
Hamada, Hiroshi
転写因子Pitx2が制御するマウスの左右非対称性
转录因子Pitx2调控小鼠左右不对称
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[原口徳子、荒神尚子、小坂田裕子、糀谷知子、小林昇平、中野めぐみ、舛本寛、Larionov, V.、Earnshaw, W. C. 平岡泰, 白鳥秀卓, 白鳥秀卓]
通讯作者:
白鳥秀卓
Analysis of the molecular mechanisms downstream of Pitx2 and left-right asymmetric morphogenesis.
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批准号:26440124
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.24万
-
财政年份:2014
-
负责人:SHIRATORI Hidetaka
-
依托单位:
Comprehensive analyses of left-right asymmetric morphogenesis in mouse
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批准号:19770194
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.44万
-
财政年份:2007
-
负责人:SHIRATORI Hidetaka
-
依托单位:
海外基金