Prevention of obesity-related diseases by food components targeting at regulation of hypoxic response in adipocytes

虽然肥胖以脂肪组织肥大为特征，但肥胖引起的低氧应激对脂肪细胞功能的影响尚不清楚。在这里，我们揭示了低氧应激刺激血管生成因子和炎性细胞因子的产生，同时伴随着脂质堆积的加速。此外，信号通路分析表明，低氧应激可激活AKT通路。综上所述，由于低氧应激引起脂肪细胞表型的变化，阐明低氧反应信号通路是诱导血管生成、炎症的重要途径，将有助于发现预防肥胖相关疾病的新靶点。

Although obesity is characterized as enlargement of adipose tissue, effect of hypoxic stress induced by obesity on the function of adipocyte is still unknown. Here, we revealed that hypoxic stress stimulated the production of angiogenic factors and inflammatory cytokines accompanied with acceleration of lipid accumulation. In addition, as a result of signaling pathway analysis, hypoxic stress evoked activation of akt pathway. Taken together, as hypoxic stress evokes variety of phenotype in adipocytes, elucidation of hypoxia responsive signaling pathways which are responsible for induction of angiogenesis, inflammation would be helpful for the discovery of novel target for the prevention of obesity related diseases.