Synthesis of structually-complex natural productsutilizing reverse-electron-demand Diels-Alder reaction

本研究的目的是开发具有空前复杂碳骨架的天然产物的高效合成方法。天然产物包括双环[2.2.2]辛烷的高效合成是通过MOB的反向电子需求Diels-Alder反应实现的，该反应可以很容易地从苯酚中制备出来。利用这种方法，我们已经实现了目标化合物氯普卡那宁和阿托紫素的高官能化碳骨架的构建。

The purpose of this study was the development of efficient synthetic methodof natural products possessing an unprecedentedly complex carbon skeleton. The efficient synthesis ofnatural products including bicyclo [2.2.2] octanes was performed by reverse-electron-demand Diels-Alderreaction of the MOB, which can be easily prepared from phenols. Using this methodology, we haveachieved the construction of the highly-functionalized carbon skeleton of target compounds, chloropupukeananin and atropurpuran.