Effect of overexposure to estrogen in fetal period on immediate allergic reaction

胎儿期过度接触雌激素对速发型过敏反应的影响

• 批准号: 22790132
• 负责人: KOBAYASHI Ryo
• 金额: $ 2.58万
• 依托单位: Gifu Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790132/
• 关键词: 胎児期影響; 免疫学; 発生・分化; 環境

Exposure to some endocrine disruptors in fetal period can affect development of reproductive organs and the immune system. However, the effect of overexposure to estrogen in the fetal period remains unclear. In the current study, we generated a transgenic mice model that expressing aromatase driven by placenta-specific promoter(Arom TG mice) and investigated the effect of overexposure to estrogen in the fetal period on immediate allergic reaction. Ovalbumin-induced active cutaneous anaphylaxis in Arom TG mice was enhanced compared with that in wild-type mice.This finding suggests that overexposure to estrogen in the fetal period may affect antigen presentation.

胎儿期暴露于某些内分泌干扰物会影响生殖器官和免疫系统的发育。然而，在胎儿期过量雌激素的影响仍不清楚。在本研究中，我们建立了一个转基因小鼠模型，表达芳香化酶的胎盘特异性启动子驱动（Arom TG小鼠），并研究了在胎儿期过度雌激素对立即过敏反应的影响。卵白蛋白诱导的Arom TG小鼠主动皮肤过敏反应较野生型小鼠增强，提示胚胎期雌激素过度暴露可能影响抗原提呈。

项目成果

胎児期エストロゲン曝露がアレルギーの感受性に及ぼす影響

胎儿雌激素暴露对过敏易感性的影响

• 发表时间: 2010
• 作者: 渡邊将作;小林亮;酒井紀行;吉田一郎;中西剛;永瀬久光
• 通讯作者: 永瀬久光