Development of antiarteriosclerosis medicines that reduced the risk of hepatotoxicity

他汀类药物是应用最广泛的降胆固醇药物。众所周知，他汀类药物可以预防动脉硬化。另一方面，他汀类药物有时也会影响肝功能，本研究的目的是比较他汀类药物抗动脉硬化作用与肝毒性作用的分子机制，通过他汀类药物的抗动脉硬化作用和肝毒性作用来发展和抑制肝毒性，从而降低肝毒性的风险，本研究表明他汀类药物对RhoA/ROOK影响的差异

Statins are the most widely used cholesterol-lowering agents. It is known that statins prevent arteriosclerosis. On the other hand, statins sometines influence the hepatic function The aimof this study is the comparison of molecular mechanism betwen anti arteriosclerosis effect and hapatotoxi ci ty by statins to develop and art eri oscl erosi s nEedi ci nes that reduced the ri sk of hepat otoxi ci ty. This study indicated the difference of the ifluence of statins against RhoA/ROOK