Molecular mechanism of regulation of bile acids in fetoplacental unit and fetal toxicities by malfunction of the placenta

本研究部分阐明了大鼠胎盘的定位和胆汁酸转运蛋白SLc10a3的分子功能，SLc10a3可能是一种调节组织和血浆胆汁酸浓度的分子，并且在胎盘中特异表达。严格控制胎儿体内胆汁酸的血浆浓度对胎儿的正常发育至关重要。本研究的发现将与胎盘功能障碍和胎儿生长缺陷之间的关系有关。

This study has partly clarified that rat placental localization and the molecular function of a bile acid transporter, Slc10a3 which is a possible molecule regulating tissue and plasma concentration of bile acids and is expressed particularly in the placenta. It is essential that plasma concentration of bile acids is strictly controlled in the fetus for the normal fetal growth. The findings in the present study will be relevant to the relationship between malfunction of the placenta and deficiency of fetal growth.