Molecular mechanism of regulation of bile acids in fetoplacental unit and fetal toxicities by malfunction of the placenta

胎儿胎盘单位胆汁酸调节的分子机制以及胎盘功能障碍引起的胎儿毒性

• 批准号: 22790171
• 负责人: NISHIMURA Tomohiro
• 金额: $ 2.58万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790171/
• 关键词: 胎児胎盤系; 血液胎盤関門; 胆汁酸; トランスポーター; 胎児毒性; 胆汁鬱滞; 肝内胆汁うっ滞症

This study has partly clarified that rat placental localization and the molecular function of a bile acid transporter, Slc10a3 which is a possible molecule regulating tissue and plasma concentration of bile acids and is expressed particularly in the placenta. It is essential that plasma concentration of bile acids is strictly controlled in the fetus for the normal fetal growth. The findings in the present study will be relevant to the relationship between malfunction of the placenta and deficiency of fetal growth.

本研究部分阐明了大鼠胎盘的定位和胆汁酸转运蛋白SLc10a3的分子功能，SLc10a3可能是一种调节组织和血浆胆汁酸浓度的分子，并且在胎盘中特异表达。严格控制胎儿体内胆汁酸的血浆浓度对胎儿的正常发育至关重要。本研究的发现将与胎盘功能障碍和胎儿生长缺陷之间的关系有关。

项目成果

Differential Expression of Ezrin and CLP36 in the Two Layers of Syncytiotrophoblast in Rats

• DOI: 10.1248/bpb.33.1400
• 发表时间: 2010-08-01
• 期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN
• 影响因子: 2
• 作者: Higuchi, Kei;Iizasa, Hisashi;Nakashima, Emi
• 通讯作者: Nakashima, Emi

Proton-coupled erythromycin antiport at rat blood-placenta barrier

质子偶联红霉素在大鼠血胎盘屏障上的反向转运

• 发表时间: 2010
• 期刊: Drug Metab.Dispos. 38
• 作者: Y.Sai;T.Nishimura;K.Ochi;N.Tanaka;A.Takagi;M.Tomi;N.Kose;Y.Kobayashi;N.Miyakoshi;S.Kitagaki;C.Mukai;E.Nakashima
• 通讯作者: E.Nakashima

Mechanism of Nucleoside Uptake in Rat Placenta and Induction of Placental CNT2 in Experimental Diabetes

大鼠胎盘核苷摄取机制及胎盘CNT2诱导实验性糖尿病

• DOI: 10.2133/dmpk.dmpk-11-rg-103
• 发表时间: 2012
• 期刊: Drug Metabolism and Pharmacokinetics
• 影响因子: 2.1
• 作者: Nishimura T;Chishu T;Tomi M;Nakamura R;Sato K;Kose N;Sai Y;Nakashima E
• 通讯作者: Nakashima E

Roles of TauT and system A in cytoprotection of rat syncytiotrophoblast cell line exposed to hypertonic stress

• DOI: 10.1016/j.placenta.2010.08.003
• 发表时间: 2010-11-01
• 期刊: PLACENTA
• 影响因子: 3.8
• 作者: Nishimura, T.;Sai, Y.;Nakashima, E.
• 通讯作者: Nakashima, E.

Enhancement of zidovudine transfer to molt-4 cells, a human t-cell model, by dehydroepiandrosterone sulfate

通过硫酸脱氢表雄酮增强齐多夫定向 molt-4 细胞（一种人类 T 细胞模型）的转移

• DOI: 10.1002/jps.22624
• 发表时间: 2011
• 期刊: J Pharm Sci
• 作者: Nishimura T;Tanaka J;Tomi M;Seki Y;Kose N;Sai Y;Nakashima E.
• 通讯作者: Nakashima E.