Effect of 1-deoxy-nor-sominone (Denosomin) on functional recovery of the injured spinal cord

在这项研究中，我们阐明了一种新的化合物，1-脱氧去人蛋白（Denosomin）通过与星形胶质细胞分泌的波形蛋白相关的轴突生长来改善脊髓损伤（SCI）。在培养的星形胶质细胞中，Denosomin能促进星形胶质细胞增殖，抑制星形胶质细胞死亡，增加vimentin的分泌。此外，波形蛋白促进了培养神经元轴突的生长。这项研究首次证明了波形蛋白在脊髓损伤中的新作用，以及药物介导的反应性星形胶质细胞特性的改变。

In this study, we clarified that a novel compound, 1-deoxy-nor-sominone (Denosomin) ameliorates spinal cord injury (SCI) via axonal growth associated with astrocyte-secreted vimentin. Denosomin increased astroglial proliferation, inhibited astroglial death and increased the secretion of vimentin in cultured astrocytes. Furthermore, vimentin promoted axonal outgrowth in cultured neurons. This study is the first to demonstrate this novel role of vimentin in SCI and drug-mediated modification of the property of reactive astrocytes.