The expression of actin-binding protein filamin in the skeletal muscle of diabetic rodents

骨骼肌胰岛素抵抗是2型糖尿病发生发展的重要原因。然而，其分子机制尚不清楚。在本研究中，我们阐明了细丝蛋白是一种肌动蛋白结合蛋白，在糖尿病啮齿动物骨骼肌中的表达比正常啮齿动物增加。这一数据表明，丝素可能对参与2型糖尿病发生发展的骨骼肌中的葡萄糖代谢具有生理功能。

The insulin resistance in skeletal muscle causes the onset and the development of type 2 diabetes mellitus. However, its molecular mechanism is unclear. In this study, we clarified the expression of filamin, which is one of actin-binding proteins, increased in the skeletal muscle of diabetic rodents compared with the normal rodents. This data indicate that filamin may have a physiological function for glucose metabolism in the skeletal muscle involved in the development of type 2 diabetes mellitus.